Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Vet Med Sci. 2022 Mar;8(2):781-791. doi: 10.1002/vms3.687. Epub 2021 Dec 13.
Management and control of metabolic disorders in sheep around parturition is important. and various researchers have suggested different managerial solutions. Butaphosphan and cyanocobalamin are widely used for curing metabolic disorders resulting from poor nutrition, inadequate management or diseases.
It was hypothesised that butaphosphan and cyanocobalamin could improve the metabolism of ewes around parturition.
Twenty-eight clinically healthy 3-year-old pregnant Afshari ewes from 21 days before parturition were enrolled into four equal groups: control (Ctrl), B+C1, B+C2 and B+C3. The Ctrl group only received intravenous normal saline and B+C1, B+C2 and B+C3 ewes, respectively, received an intravenous combination of 10% butaphosphan and 0.005% cyanocobalamin at 2, 4 and 6 ml/ewe, on Days 19-21, 10-12 and 1-3 before parturition. Blood samples were taken from all the ewes on Days 21, 12 and 3 before lambing at parturition day and on days 3, 12 and 21 after parturition. A body condition score of all the ewes was assessed at blood sampling days, and lambs born from the ewes were weighed at birth and every 2 weeks up to 3 months. Serum concentrations of glucose, cortisol, non-esterified fatty acids, beta-hydroxy butyric acid, triglyceride, cholesterol, high-, low- and very-low-density lipoproteins, aspartate aminotransferase and alanine aminotransferase were measured.
This drug combination decreased circulating glucose, cortisol, lipid profile and hepatic enzymes via dose-dependent manner, 6 ml of this drug compound/ewe was more potent than 4 and 2 ml/ewe. The lambs' weight from mothers receiving 6 ml of this combination was significantly higher than those of the others.
It may be suggested that the intravenous administration of 6 ml/ewe of this combination for 3 consecutive days in three states before parturition had prophylactic effects on metabolic disorders of ewes and enhanced the lambs weight gain after birth.
在分娩前后，管理和控制绵羊的代谢紊乱非常重要。许多研究人员提出了不同的管理解决方案。但膦酸盐和氰钴胺素被广泛用于治疗因营养不良、管理不善或疾病引起的代谢紊乱。
本研究假设但膦酸盐和氰钴胺素可以改善分娩前后母羊的代谢。
将 28 只临床健康的 3 岁怀孕阿法什里母羊从分娩前 21 天开始分为四组：对照组（Ctrl）、B+C1 组、B+C2 组和 B+C3 组。对照组仅静脉注射生理盐水，B+C1、B+C2 和 B+C3 组母羊分别在分娩前 19-21 天、10-12 天和 1-3 天，每只羊静脉注射 10%但膦酸盐和 0.005%氰钴胺素，剂量分别为 2、4 和 6ml/只。在分娩当天和分娩前 21、12 和 3 天采集所有母羊的血液样本，在产后 3、12 和 21 天采集血液样本。在采血日评估所有母羊的体况评分，从母羊出生的羔羊在出生时和每 2 周称重至 3 个月。测量血清葡萄糖、皮质醇、非酯化脂肪酸、β-羟丁酸、甘油三酯、胆固醇、高低密度脂蛋白、极低密度脂蛋白、天门冬氨酸氨基转移酶和丙氨酸氨基转移酶浓度。
这种药物组合通过剂量依赖的方式降低了循环葡萄糖、皮质醇、脂质谱和肝酶，6ml/只这种药物比 4ml/只和 2ml/只更有效。接受这种组合 6ml/只的母羊的羔羊体重明显高于其他母羊。
建议在分娩前连续 3 天，每天给每只羊静脉注射 6ml 这种组合，可以预防母羊的代谢紊乱，并增强羔羊出生后的体重增加。
