Özalp R G, Yavuz A, Orman A, Seker I, Udum Küçükşen D, Rişvanlı A, Demiral Ö O, Wehrend A
Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Uludag University, Bursa, Turkey.
Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Uludag University, Bursa, Turkey.
Theriogenology. 2017 Jan 1;87:141-147. doi: 10.1016/j.theriogenology.2016.08.016. Epub 2016 Aug 22.
The clinical effects of aglepristone treatment to induce parturition in ewes and their newborns were reported. Three experimental groups were defined: group AG5 (n = 5), group AG10 (n = 5), and group CG (n = 5) in which ewes were injected twice with 5, 10 mg/kg of aglepristone, and saline solution of ewes, respectively. Different parameters associated with parturition in ewes and their newborns were investigated. Serum progesterone, oxytocin, and free and conjugated total estrogens were measured after treatments until parturition. No statistical difference was found from first aglepristone administration to onset of lambing between AG5 and AG10 (23.90 ± 6.20, 40.00 ± 6.71 hours). Parturition induction in two groups shortened the gestational length significantly compared with the control group (P = 0.003). Dystocia was observed in two ewes in group AG10. The placental weight showed statistically significant difference only between the AG10 and CG (P = 0.039), but no difference was observed in the placental expulsion period between the groups. Decrease in food consumption 24 to 36 hours after parturition in all ewes and skin necrosis in an ewe in group AG5 were observed. Progesterone concentration was significantly lower in AG5 than that in ewes in group AG10 and CG (P < 0.05). No difference was observed in concentrations of free total estrogens and oxytocin between groups. The body temperature of lambs was significantly different between AG10 and CG groups both right after (P = 0.011) and 12 hours after parturition (P = 0.014). The lambs in CG had the highest mean birth weight (4.29 ± 0.28 kg), which was significantly different from the induced groups. No significant difference of blood pH and blood gases values between groups was identified both at birth and 12 hours after parturition for lambs. Significant differences could clearly be observed in total protein and blood urea nitrogen and total protein findings 12 hours after parturition (P < 0.05), whereas no difference was found in blood glucose, albumin, inorganic phosphor, triglyceride, or total cholesterol parameters. The results of this study show that the administration of aglepristone to induce parturition can precisely control lambing time without any side effects in either mothers or lambs.
报告了阿格来司酮诱导母羊分娩及其对新生羔羊临床效果的研究。实验分为三组：AG5组（n = 5）、AG10组（n = 5）和CG组（n = 5），分别对母羊注射5 mg/kg、10 mg/kg的阿格来司酮以及生理盐水。研究了与母羊及其新生羔羊分娩相关的不同参数。在处理后至分娩前测量血清孕酮、催产素、游离及结合型总雌激素水平。AG5组和AG10组从首次注射阿格来司酮到产羔开始的时间无统计学差异（分别为23.90 ± 6.20、40.00 ± 6.71小时）。与对照组相比，两组诱导分娩均显著缩短了妊娠期（P = 0.003）。AG10组有两只母羊出现难产。胎盘重量仅在AG10组和CG组之间存在统计学显著差异（P = 0.039），但各组之间胎盘排出时间无差异。观察到所有母羊在分娩后24至36小时采食量下降，AG5组有一只母羊出现皮肤坏死。AG5组孕酮浓度显著低于AG10组和CG组母羊（P < 0.05）。各组游离总雌激素和催产素浓度无差异。AG10组和CG组羔羊在出生后即刻（P = 0.011）和分娩后12小时（P = 0.014）体温存在显著差异。CG组羔羊平均出生体重最高（4.29 ± 0.28 kg），与诱导组有显著差异。羔羊出生时及出生后12小时，各组间血液pH值和血气值无显著差异。分娩后12小时，总蛋白和血尿素氮及总蛋白结果有显著差异（P < 0.05），而血糖、白蛋白、无机磷、甘油三酯或总胆固醇参数无差异。本研究结果表明，使用阿格来司酮诱导分娩可精确控制产羔时间，且对母羊和羔羊均无任何副作用。
