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富含血小板血浆在骨骼肌损伤与修复中的生物学应用

The Biological Use of Platelet-Rich Plasma in Skeletal Muscle Injury and Repair.

作者信息

Boivin Jordan, Tolsma Rachael, Awad Peter, Kenter Keith, Li Yong

机构信息

Department of Orthopaedic Surgery, Biomedical Engineering at Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA.

Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, Michigan, USA.

出版信息

Am J Sports Med. 2023 Apr;51(5):1347-1355. doi: 10.1177/03635465211061606. Epub 2021 Dec 14.

DOI:10.1177/03635465211061606
PMID:34904902
Abstract

Platelet-rich plasma (PRP) is a blood product that contains several growth factors and active proteins. PRP is thought to be used autologously to assist in the repair of injured tissues as well as to treat pain at the site of injury. The mechanism behind PRP in regenerative medicine has been well investigated and includes the identification and concentration of released growth factors and exosomes. The benefits of PRP have been highly recommended and are used widely in orthopaedics and sports medicine, including repair of injured skeletal muscle. This current report summarizes some of the more recent studies in the use of PRP as it relates to muscle healing, in both the in vitro and clinical arenas.

摘要

富血小板血浆(PRP)是一种含有多种生长因子和活性蛋白的血液制品。PRP被认为可自体使用,以协助受损组织的修复以及治疗损伤部位的疼痛。再生医学中PRP背后的机制已得到充分研究,包括对释放的生长因子和外泌体的识别与浓缩。PRP的益处已得到高度推荐,并广泛应用于骨科和运动医学,包括受损骨骼肌的修复。本报告总结了一些关于PRP在体外和临床领域与肌肉愈合相关的最新研究。

相似文献

1
The Biological Use of Platelet-Rich Plasma in Skeletal Muscle Injury and Repair.富含血小板血浆在骨骼肌损伤与修复中的生物学应用
Am J Sports Med. 2023 Apr;51(5):1347-1355. doi: 10.1177/03635465211061606. Epub 2021 Dec 14.
2
Postinjury Exercise and Platelet-Rich Plasma Therapies Improve Skeletal Muscle Healing in Rats But Are Not Synergistic When Combined.损伤后运动和富血小板血浆疗法可改善大鼠骨骼肌愈合,但联合使用时并无协同作用。
Am J Sports Med. 2017 Jul;45(9):2131-2141. doi: 10.1177/0363546517702864. Epub 2017 Apr 28.
3
Platelet-Rich Plasma Releasate Promotes Regeneration and Decreases Inflammation and Apoptosis of Injured Skeletal Muscle.富含血小板的血浆释放物可促进受损骨骼肌的再生,减少炎症和细胞凋亡。
Am J Sports Med. 2018 Jul;46(8):1980-1986. doi: 10.1177/0363546518771076. Epub 2018 May 17.
4
Customized platelet-rich plasma with transforming growth factor β1 neutralization antibody to reduce fibrosis in skeletal muscle.定制的富含血小板血浆与转化生长因子β1中和抗体以减少骨骼肌纤维化。
Biomaterials. 2016 May;87:147-156. doi: 10.1016/j.biomaterials.2016.02.017. Epub 2016 Feb 17.
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Influence of Platelet-Rich and Platelet-Poor Plasma on Endogenous Mechanisms of Skeletal Muscle Repair/Regeneration.富血小板血浆和贫血小板血浆对骨骼肌修复/再生内源性机制的影响。
Int J Mol Sci. 2019 Feb 5;20(3):683. doi: 10.3390/ijms20030683.
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The effect of platelet-rich plasma on muscle contusion healing in a rat model.富血小板血浆对大鼠模型肌肉挫伤愈合的影响。
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The use of platelet-rich plasma in arthroscopy and sports medicine: optimizing the healing environment.富血小板血浆在关节镜和运动医学中的应用:优化愈合环境。
Arthroscopy. 2010 Feb;26(2):269-78. doi: 10.1016/j.arthro.2009.11.015.
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Platelet-rich plasma (PRP) for acute muscle injury: a systematic review.富血小板血浆(PRP)治疗急性肌肉损伤:一项系统评价。
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Sports medicine applications of platelet rich plasma.富血小板血浆在运动医学中的应用。
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Platelet-rich plasma products in sports medicine.运动医学中的富血小板血浆制品。
Phys Sportsmed. 2011 Sep;39(3):94-9. doi: 10.3810/psm.2011.09.1925.

引用本文的文献

1
Controlled delivery of PRP from decellularized extracellular matrix enhances skeletal muscle regeneration.从脱细胞细胞外基质中可控递送富血小板血浆可增强骨骼肌再生。
Sci Rep. 2025 Apr 13;15(1):12719. doi: 10.1038/s41598-025-92319-8.
2
Novel Ultrasound Examination and Guided Intervention of Peri-Oral Musculature and Fascia in Wind Players with Embouchure Problems: Technical Note.针对存在吹奏口型问题的管乐器演奏者口周肌肉和筋膜的新型超声检查及引导干预:技术说明
Diagnostics (Basel). 2025 Feb 20;15(5):514. doi: 10.3390/diagnostics15050514.
3
Case series: effects of platelet-rich plasma (PRP) on the recovery of bilateral muscle injuries after removal of semitendinosus and gracilis grafts in bilateral anterior cruciate ligament (ACL) reconstruction.
病例系列:富血小板血浆(PRP)对双侧前交叉韧带(ACL)重建术中半腱肌和股薄肌移植物取出后双侧肌肉损伤恢复的影响。
J Surg Case Rep. 2025 Feb 10;2025(2):rjae641. doi: 10.1093/jscr/rjae641. eCollection 2025 Feb.
4
Enhancing Cartilage Repair: Surgical Approaches, Orthobiologics, and the Promise of Exosomes.增强软骨修复:手术方法、骨生物制剂与外泌体的前景
Life (Basel). 2024 Sep 11;14(9):1149. doi: 10.3390/life14091149.
5
Traumatic muscle injury.创伤性肌肉损伤。
Nat Rev Dis Primers. 2023 Oct 19;9(1):56. doi: 10.1038/s41572-023-00469-8.
6
Current State of Platelet-rich Plasma in the Treatment of Rheumatic Disease: A Retrospective Review of the Literature.富血小板血浆治疗风湿性疾病的现状:文献回顾性研究。
Curr Rheumatol Rev. 2023;19(4):400-407. doi: 10.2174/1573397119666230420112017.
7
A comparison of different physical stimulation combined with platelet-rich plasma for the treatment of knee osteoarthritis: study protocol for a randomized controlled trial.不同物理刺激联合富血小板血浆治疗膝骨关节炎的比较:一项随机对照试验研究方案。
Trials. 2023 Mar 17;24(1):200. doi: 10.1186/s13063-023-07228-w.