Hyuha Gimbo M, Sawe Hendry R, Kilindimo Said, Mussa Raya Y, Gulamhussein Masuma A, Rwegoshora Shamila S, Shayo Frida, Mdundo Winnie, Mfinanga Juma A, Weber Ellen J
Emergency Medicine Department, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania.
Emergency Medicine Department, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Int J Emerg Med. 2021 Dec 14;14(1):72. doi: 10.1186/s12245-021-00395-0.
Due to the high prevalence of human immunodeficiency virus (HIV) in Tanzania, provider-initiated HIV testing for patients attending any health care setting is recommended. However, follow-up and linkage to care by those tested remain poor. We determined the feasibility and efficacy of text messaging to promote follow-up among otherwise healthy trauma patients who underwent provider-initiated HIV testing and counseling at an emergency department (ED) in Tanzania.
This randomized controlled trial (RCT) was conducted at Muhimbili National Hospital (MNH) ED between September 2019 and February 2020. Adult trauma patients consenting to HIV testing and follow-up text messaging were randomized to standard care (pre-test and post-test counseling) or standard care plus a series of three short message service (SMS) text message reminders for follow-up in an HIV clinic, if positive, or for retesting, if negative. Investigators blinded to the study assignment called participants 2 months after the ED visit if HIV-positive or 4 months if HIV-negative. We compared the proportion of people in the intervention and control groups completing recommended follow-up. Secondary outcomes were the proportion of patients agreeing to testing, proportion of patients agreeing to receiving text messages, and the proportion of HIV-positive and HIV-negative patients in each study arm who followed up.
Of the 290 patients approached, 255 (87.9%) opted-in for testing and agreed to receive a text message. The median age of the study population was 29 [IQR 24-40] years. There were 127 patients randomized to the intervention group and 128 to the control group. The automated SMS system verified that 381 text messages in total were successfully sent. We traced 242 (94.9%) participants: 124 (51.2%) in the intervention group and 18 (488%) in the control group. A total of 100 (39.2%) subjects reported completing a follow-up visit, of which 77 (60.6%) were from the intervention group and 23 (17.9%) were from the control group (RR = 3.4, 95% CI 2.3-5.0). This resulted in a number needed to treat (NNT) of 2.3. Of the 246 HIV-negative participants, 37% underwent repeat screening: 59% of those in the intervention group and 16% in the control group (RR = 3.7, P = < 0.0001, NNT 2.3). Among the nine positive patients, all five in the intervention group and only three in the controls had follow-up visits.
Automated text message is a feasible and effective way to increase follow-up in HIV-tested individuals in a limited income country.
由于坦桑尼亚人类免疫缺陷病毒(HIV)的高流行率,建议为在任何医疗机构就诊的患者提供由医护人员主动发起的HIV检测。然而,接受检测者的后续跟进及护理衔接情况仍然较差。我们确定了短信提醒在促进坦桑尼亚一家急诊科接受医护人员主动发起的HIV检测和咨询的健康创伤患者进行后续跟进方面的可行性和有效性。
这项随机对照试验(RCT)于2019年9月至2020年2月在穆希姆比利国家医院(MNH)急诊科进行。同意接受HIV检测及后续跟进短信提醒的成年创伤患者被随机分为标准护理组(检测前和检测后咨询)或标准护理加一系列三条短信提醒组,若检测结果为阳性,则提醒其前往HIV诊所进行后续跟进,若为阴性,则提醒其再次检测。对研究分组不知情的研究人员在急诊就诊后2个月致电HIV检测呈阳性的参与者,或在4个月后致电检测呈阴性的参与者。我们比较了干预组和对照组中完成推荐后续跟进的人员比例。次要结果包括同意检测的患者比例、同意接收短信的患者比例,以及每个研究组中接受后续跟进的HIV阳性和HIV阴性患者的比例。
在接触的290名患者中,255名(87.9%)选择接受检测并同意接收短信。研究人群的中位年龄为29岁[四分位间距24 - 40岁]。127名患者被随机分配到干预组,128名被分配到对照组。自动短信系统核实共成功发送了381条短信。我们追踪到了242名(94.9%)参与者:干预组124名(51.2%),对照组18名(48.8%)。共有100名(39.2%)受试者报告完成了后续就诊,其中77名(60.6%)来自干预组,23名(17.9%)来自对照组(相对危险度 = 3.4,95%置信区间2.3 - 5.0)。这导致治疗所需人数(NNT)为2.三名患者中,干预组的5名和对照组的3名进行了后续就诊。
在低收入国家,自动短信提醒是增加接受HIV检测者后续跟进的一种可行且有效的方式。