Bao Terigen, Liu Jia, Leng Jiyan, Cai Lu
Department of Geriatrics, The First Hospital of Jilin University, Changchun, 130021, China.
Department of Pediatrics, The Pediatric Research Institute, The University of Louisville School of Medicine, Louisville, KY, 40292, USA.
Cell Biosci. 2021 Dec 14;11(1):209. doi: 10.1186/s13578-021-00724-z.
In the classic Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway, downstream signals can control the production of type I interferon and nuclear factor kappa-light-chain-enhancer of activated B cells to promote the activation of pro-inflammatory molecules, which are mainly induced during antiviral responses. However, with progress in this area of research, studies focused on autoimmune diseases and chronic inflammatory conditions that may be relevant to cGAS-STING pathways have been conducted. This review mainly highlights the functions of the cGAS-STING pathway in chronic inflammatory diseases. Importantly, the cGAS-STING pathway has a major impact on lipid metabolism. Different research groups have confirmed that the cGAS-STING pathway plays an important role in the chronic inflammatory status in various organs. However, this pathway has not been studied in depth in diabetes and diabetes-related complications. Current research on the cGAS-STING pathway has shown that the targeted therapy of diseases that may be caused by inflammation via the cGAS-STING pathway has promising outcomes.
在经典的环磷酸鸟苷-磷酸腺苷（cGAMP）合成酶（cGAS）-干扰素基因刺激因子（STING）途径中，下游信号可控制I型干扰素的产生以及活化B细胞核因子κB轻链增强子，以促进促炎分子的激活，这些促炎分子主要在抗病毒反应期间被诱导产生。然而，随着该研究领域的进展，已经开展了针对可能与cGAS-STING途径相关的自身免疫性疾病和慢性炎症性疾病的研究。本综述主要强调cGAS-STING途径在慢性炎症性疾病中的功能。重要的是，cGAS-STING途径对脂质代谢有重大影响。不同研究小组已证实，cGAS-STING途径在各个器官的慢性炎症状态中发挥重要作用。然而，该途径在糖尿病及糖尿病相关并发症方面尚未得到深入研究。目前关于cGAS-STING途径的研究表明，通过cGAS-STING途径对可能由炎症引起的疾病进行靶向治疗具有良好前景。
