Cancer Cell. 2021 Dec 13;39(12):1549-1552. doi: 10.1016/j.ccell.2021.11.010.
T cells mediate anti-tumor immune responses and are the key target of immune checkpoint therapy, but they can also promote immune tolerance. A clear understanding of the specific contributions and biology of different T cell subsets is required to fully harness the curative potential of immunotherapies. Experts discuss the state of the field and key challenges for moving forward.
T 细胞介导抗肿瘤免疫反应，是免疫检查点治疗的关键靶点，但也能促进免疫耐受。为了充分发挥免疫疗法的治疗潜力，需要清楚地了解不同 T 细胞亚群的具体作用和生物学特性。专家们讨论了该领域的现状和前进的关键挑战。
