不同注射剂量下碘海醇的血浆清除率比较研究。

Comparative study of plasma clearance of iohexol at different injection doses.

机构信息

Department of Clinical Laboratory, Civil Aviation General Hospital, Beijing, China; Peking University Civil Aviation School of Clinical Medicine, Beijing, China.

Beijing Institute of Medical Device Testing, Beijing, China; NMPA Key Laboratory for Quality Evaluation of In Vitro Diagnostics, Beijing, China.

出版信息

Clin Chim Acta. 2022 Jan 15;525:34-39. doi: 10.1016/j.cca.2021.12.009. Epub 2021 Dec 11.

DOI:10.1016/j.cca.2021.12.009

PMID:34906558

Abstract

BACKGROUND

Our goal was to compare the metabolic curves of plasma clearance of iohexol (Cl) at standard dose (5 ml) and contrast-level dose (50 ml).

METHODS

The concentration of iohexol was measured at fasting state and at nine different time periods after a single bolus of iohexol injection. The interval between the injection of the two doses was longer than 24 hrs. Using a multi-point method and a dual-sample method, Cl and Cl were calculated, and the correlation and consistency of Cl between the two doses were compared.

RESULTS

The metabolic curves of iohexol at the 5 ml and 50 ml injection were substantially identical. The correlation of Cl between the two doses was 0.930, the mean deviation was 1.3 ± 6.9 ml/min/1.73 m. Taking Cl as the standard, the Cl at 2 h and 4 h had a correlation coefficient of 0.975, a mean deviation of 0.1 ± 5.3 ml/min/1.73 m, and the concordances were 100% corresponding to P, 88.9% corresponding to P, and 77.8% corresponding to P.

CONCLUSION

When a regular dose of iohexol is used for enhanced CT, Cl can be used for the measurement of GFR, and a proper time for blood collection can be 2 h and 4 h.

摘要

背景

我们的目标是比较标准剂量（5ml）和对比剂剂量（50ml）单次推注碘海醇后血浆清除率的代谢曲线。

方法

在空腹状态和单次碘海醇注射后 9 个不同时间点测量碘海醇的浓度。两种剂量之间的注射间隔超过 24 小时。采用多点法和双样本法计算 Cl 和 Cl，比较两种剂量之间 Cl 的相关性和一致性。

结果

5ml 和 50ml 注射碘海醇的代谢曲线基本一致。两种剂量之间 Cl 的相关性为 0.930，平均偏差为 1.3±6.9ml/min/1.73m。以 Cl 为标准，2h 和 4h 时 Cl 的相关系数为 0.975，平均偏差为 0.1±5.3ml/min/1.73m，一致性分别为 100%（P＜0.001）、88.9%（P＜0.001）和 77.8%（P＜0.001）。