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使用生物信息学分析鉴定结直肠癌的潜在核心基因和结直肠癌肝转移的关键基因。

Identification of potential core genes in colorectal carcinoma and key genes in colorectal cancer liver metastasis using bioinformatics analysis.

机构信息

Graduate School, Hebei North University, Zhangjiakou, 075000, Hebei, China.

Fuyong People's Hospital, Shenzhen, Guangdong, 518103, China.

出版信息

Sci Rep. 2021 Dec 14;11(1):23938. doi: 10.1038/s41598-021-03395-5.

DOI:10.1038/s41598-021-03395-5
PMID:34907282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8671463/
Abstract

Colorectal carcinoma (CRC) is one of the most prevalent malignant tumors worldwide. Meanwhile, the majority of CRC related deaths results from liver metastasis. Gene expression profile of CRC patients with liver Metastasis was identified using 4 datasets. The data was analyzed using GEO2R tool. GO and KEGG pathway analysis were performed. PPI network of the DEGs between 1 and 2 gene sets was also constructed. The set 1 is named between primary CRC tissues and metastatic CRC tissues. The set 2 is named between primary CRC tissues and normal tissues. Finally, the prognostic value of hub genes was also analyzed. 35 DEGs (set 1) and 142 DEGs (set 2) were identified between CRC liver metastatic cancer patients. The PPI network was constructed using the top 10 set 1 hub genes which included AHSG, SERPINC1, FGA, F2, CP, ITIH2, APOA2, HPX, PLG, HRG and set 2 hub genes which included TIMP1, CXCL1, COL1A2, MMP1, AURKA, UBE2C, CXCL12, TOP2A, ALDH1A1 and PRKACB. Therefore, ITIH2 might represent the potential core gene for colon cancer liver metastasis. COL1A2 behaves as a key gene in colorectal carcinoma.

摘要

结直肠癌（CRC）是全球最常见的恶性肿瘤之一。同时，大多数与 CRC 相关的死亡是由肝转移引起的。使用 4 个数据集鉴定了具有肝转移的 CRC 患者的基因表达谱。使用 GEO2R 工具分析数据。进行 GO 和 KEGG 通路分析。还构建了 DEGs 在 1 和 2 个基因集之间的 PPI 网络。集 1 命名为原发性 CRC 组织和转移性 CRC 组织之间。集 2 命名为原发性 CRC 组织和正常组织之间。最后，还分析了关键基因的预后价值。在 CRC 肝转移性癌症患者中鉴定出 35 个 DEGs（集 1）和 142 个 DEGs（集 2）。使用前 10 个集 1 枢纽基因（包括 AHSG、SERPINC1、FGA、F2、CP、ITIH2、APOA2、HPX、PLG、HRG）和集 2 枢纽基因（包括 TIMP1、CXCL1、COL1A2、MMP1、AURKA、UBE2C、CXCL12、TOP2A、ALDH1A1 和 PRKACB）构建了 PPI 网络。因此，ITIH2 可能代表结肠癌肝转移的潜在核心基因。COL1A2 是结直肠癌的关键基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/0ba0d507c163/41598_2021_3395_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/ce249599c56a/41598_2021_3395_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/8d2b158b4bf7/41598_2021_3395_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/d8ae9f0a430f/41598_2021_3395_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/b7d069e73987/41598_2021_3395_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/ca6d3ddc2d43/41598_2021_3395_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/773aad437b31/41598_2021_3395_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/3fad6d30536b/41598_2021_3395_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/0ba0d507c163/41598_2021_3395_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/ce249599c56a/41598_2021_3395_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/8d2b158b4bf7/41598_2021_3395_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/d8ae9f0a430f/41598_2021_3395_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/b7d069e73987/41598_2021_3395_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/ca6d3ddc2d43/41598_2021_3395_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/773aad437b31/41598_2021_3395_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/3fad6d30536b/41598_2021_3395_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b39/8671463/0ba0d507c163/41598_2021_3395_Fig8_HTML.jpg

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