Banagozar Mohammadi Ahad, Sadigh-Eteghad Saeed, Torbati Mohammadali, Bagher Fazljou Seyyed Mohammad, Vatandoust Seyed Mehdi, Ej Golzari Samad, Farajdokht Fereshteh, Mahmoudi Javad
Tabriz University of Medical Sciences, Faculty of Traditional Medicine, Department of Traditional Medicine, Tabriz, Iran.
Tabriz University of Medical Sciences, Neurosciences Research Center (NSRC), Tabriz, Iran.
J Appl Biomed. 2019 Sep;17(3):147-156. doi: 10.32725/jab.2019.012. Epub 2019 Aug 14.
In traditional medicine, natural silk is regarded as a cognitive enhancer and a cure for ameliorating the symptoms of heart disease, atherosclerosis, and metabolic disorders. In this review, general characteristics of both silk proteins, fibroin and sericin, extracted from silkworm Bombyx mori and their potential use in the neuronal disorders was discussed. Evidence shows that silk proteins exhibit neuroprotective effects in models of neurotoxicity. The antioxidant, neuroprotective, and acetylcholinesterase inhibitory mechanisms of silk proteins could prove promising in the treatment of neurodegenerative diseases. Owing to their excellent neurocompatibility and physicochemical properties, silk proteins have been used as scaffolds and drug delivery materials in the neuronal tissue engineering. These data support the potential of silk proteins as an effective complementary agent for central and peripheral neurological disorders.
在传统医学中，天然蚕丝被视为一种认知增强剂，可用于缓解心脏病、动脉粥样硬化和代谢紊乱的症状。在本综述中，讨论了从家蚕中提取的两种丝蛋白（丝素蛋白和丝胶蛋白）的一般特性及其在神经疾病中的潜在用途。有证据表明，丝蛋白在神经毒性模型中具有神经保护作用。丝蛋白的抗氧化、神经保护和乙酰胆碱酯酶抑制机制在神经退行性疾病的治疗中可能很有前景。由于其出色的神经相容性和物理化学性质，丝蛋白已被用作神经组织工程中的支架和药物递送材料。这些数据支持了丝蛋白作为中枢和外周神经疾病有效补充剂的潜力。
