Milutinovic Milica, Velickovic Radovanovic Radmila, Savikin Katarina, Radenkovic Sasa, Arvandi Marjan, Pesic Milica, Kostic Milica, Miladinovic Bojana, Brankovic Suzana, Kitic Dusanka
University of Nis, Faculty of Medicine, Department of Pharmacy, Nis, Serbia.
University of Nis, Faculty of Medicine, Department of Pharmacology, Nis, Serbia.
J Appl Biomed. 2019 Dec;17(4):218-224. doi: 10.32725/jab.2019.020. Epub 2019 Nov 13.
Recent literature evidence indicates the potential use of chokeberry preparations in the prevention and treatment of some chronic noncommunicable diseases. The aim of the present study was to evaluate the effects of the three months oral chokeberry juice supplementation in type 2 diabetic patients, as well as its influence on hematological parameters and certain parameters of the renal dysfunction. The study was designed as an open-label trial, which included 35 patients who have received the herbal supplement, polyphenol-rich chokeberry juice (150 ml/day, three times a day for 50 ml), in addition to their standard therapy. Chokeberry juice as a rich source of polyphenol compounds could be an effective preventive and therapeutic agent in diabetes mellitus type 2. Hematological and biochemical parameters were measured at baseline, after 3 months with the chokeberry juice supplementation and after the next 3 months without the chokeberry juice supplementation (follow-up period). Significant difference was noticed in the levels of LDL-cholesterol, glycated hemoglobin and serum creatinine (p < 0.05), as well as in the levels of some hematological parameters, such as white blood cell and lymphocyte count (p < 0.01), hematocrit, blood hemoglobin, mean corpuscular volume, hemoglobin and hemoglobin concentration and red blood cell count (p < 0.05). The daily consumption of the chokeberry juice could improve the health status in patients with type 2 diabetes mellitus, in combination with their standard therapy.
近期文献证据表明，黑果腺肋花楸制剂在预防和治疗某些慢性非传染性疾病方面具有潜在用途。本研究的目的是评估连续三个月口服黑果腺肋花楸汁对2型糖尿病患者的影响，以及其对血液学参数和肾功能不全某些参数的影响。该研究设计为开放标签试验，纳入了35例患者，这些患者除接受标准治疗外，还接受了富含多酚的黑果腺肋花楸汁草药补充剂（150毫升/天，分三次服用，每次50毫升）。黑果腺肋花楸汁作为多酚化合物的丰富来源，可能是2型糖尿病的一种有效预防和治疗药物。在基线、补充黑果腺肋花楸汁3个月后以及接下来不补充黑果腺肋花楸汁的3个月随访期后，测量血液学和生化参数。观察到低密度脂蛋白胆固醇、糖化血红蛋白和血清肌酐水平有显著差异（p<0.05），以及一些血液学参数水平，如白细胞和淋巴细胞计数（p<0.01）、血细胞比容、血红蛋白、平均红细胞体积、血红蛋白和血红蛋白浓度以及红细胞计数（p<0.05）。每日饮用黑果腺肋花楸汁结合标准治疗可改善2型糖尿病患者的健康状况。
