Sedivy Petr, Dezortova Monika, Rydlo Jan, Drobny Miloslav, Krssak Martin, Valkovic Ladislav, Hajek Milan
Institute for Clinical and Experimental Medicine, Department of Diagnostic and Interventional Radiology, MR-unit, Prague, Czech Republic.
Medical University of Vienna, Department of Internal Medicine III & High Field MR Centre, Division of Endocrinology and Metabolism, Department of Biomedical Imaging and Image guided Therapy, Vienna, Austria.
J Appl Biomed. 2019 Jun;17(2):91-98. doi: 10.32725/jab.2019.006. Epub 2019 Apr 15.
Magnetic Resonance (MR) compatible ergometers are specialized ergometers used inside the MR scanners for the characterization of tissue metabolism changes during physical stress. They are most commonly used for dynamic phosphorous magnetic resonance spectroscopy (31P MRS), but can also be used for lactate production measurements, perfusion studies using arterial spin labelling or muscle oxygenation measurements by blood oxygen dependent contrast sequences. We will primarily discuss the importance of ergometers in the context of dynamic 31P MRS. Dynamic 31P MRS can monitor muscle fatigue and energy reserve during muscle contractions as well as the dynamics of recuperation of skeletal muscle tissue during the following recovery through signal changes of phosphocreatine (PCr), inorganic phosphate and adenosine triphosphate (ATP). Based on the measured data it is possible to calculate intracellular pH, metabolic flux of ATP through creatine-kinase reaction, anaerobic glycolysis and oxidative phosphorylation and other metabolic parameters as mitochondrial capacity. This review primarily focuses on describing various technical designs of MR compatible ergometers for dynamic 31P MRS that must be constructed with respect to the presence of magnetic field. It is also expected that the construction of ergometers will be easy for the handling and well accepted by examined subjects.
磁共振（MR）兼容测力计是一种专门的测力计，用于磁共振扫描仪内部，以表征身体应激期间的组织代谢变化。它们最常用于动态磷磁共振波谱（31P MRS），但也可用于乳酸生成测量、使用动脉自旋标记的灌注研究或通过血氧依赖对比序列进行的肌肉氧合测量。我们将主要讨论测力计在动态31P MRS背景下的重要性。动态31P MRS可以通过磷酸肌酸（PCr）、无机磷酸盐和三磷酸腺苷（ATP）的信号变化，监测肌肉收缩期间的肌肉疲劳和能量储备，以及随后恢复过程中骨骼肌组织的恢复动态。根据测量数据，可以计算细胞内pH值、通过肌酸激酶反应的ATP代谢通量、无氧糖酵解和氧化磷酸化以及其他代谢参数，如线粒体容量。本综述主要侧重于描述用于动态31P MRS的MR兼容测力计的各种技术设计，这些设计必须考虑磁场的存在进行构建。预计测力计的构造便于操作，并能被受检者广泛接受。
