Department of Pediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Vaccine and Infectious Disease Institute, Laboratory of Medical Microbiology, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
J Infect Dis. 2022 Aug 12;226(Suppl 1):S79-S86. doi: 10.1093/infdis/jiab519.
Knowledge about how older adults get a respiratory infection is crucial for planning preventive strategies. We aimed to determine how contact with young children living outside of the household affects the risk of acute respiratory tract infections (ARTI) in community-dwelling older adults.
This study is part of the European RESCEU older adult study. Weekly surveillance was performed to detect ARTI throughout 2 winter seasons (2017-2018, 2018-2019). Child exposure, defined as having regular contact with children under 5 living outside of the subject's household, was assessed at baseline. The average attributable fraction was calculated to determine the fraction of ARTI explained by exposure to these children.
We prospectively established that 597/1006 (59%) participants experienced at least 1 ARTI. Child exposure increased the risk of all-cause ARTI (adjusted odds ratio [aOR], 1.58; 95% confidence interval [CI], 1.21 -2.08; P = .001). This risk was highest in those with the most frequent contact (aOR, 1.80; 95% CI, 1.23-2.63; P = .003). The average attributable fraction of child exposure explaining ARTI was 10% (95% CI, 5%-15%).
One of 10 ARTI in community-dwelling older adults is attributable to exposure to preschool children living outside of the household.
NCT03621930.
了解老年人如何感染呼吸道疾病对于制定预防策略至关重要。我们旨在确定与居住在家庭之外的幼儿接触如何影响社区居住的老年人急性呼吸道感染（ARTI）的风险。
本研究是欧洲 RESCEU 老年研究的一部分。在两个冬季（2017-2018 年，2018-2019 年）期间每周进行监测以检测 ARTI。在基线时评估儿童暴露情况，定义为与居住在受试者家庭之外的 5 岁以下儿童有定期接触。计算平均归因分数以确定因接触这些儿童而导致的 ARTI 比例。
我们前瞻性地确定了 597/1006（59%）名参与者至少经历了 1 次 ARTI。儿童暴露增加了所有原因 ARTI 的风险（调整后的优势比[aOR]，1.58；95%置信区间[CI]，1.21-2.08；P =.001）。与接触最频繁的人相比，这种风险最高（aOR，1.80；95%CI，1.23-2.63；P =.003）。儿童暴露解释 ARTI 的平均归因分数为 10%（95%CI，5%-15%）。
在社区居住的老年人中，每 10 例 ARTI 中有 1 例归因于与居住在家庭之外的学龄前儿童接触。
NCT03621930。
