上海儿童呼吸道感染患者中人博卡病毒的研究：一项回顾性研究。
Human bocavirus in children with respiratory tract infection in Shanghai: a retrospective study.
机构信息
Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai, 201102, China.
出版信息
World J Pediatr. 2010 Feb;6(1):65-70. doi: 10.1007/s12519-010-0009-2. Epub 2010 Feb 9.
BACKGROUND
Human bocavirus (HBoV) was first reported in 2005. The worldwide presence of HBoV in children with acute respiratory tract infection (ARTI) has been confirmed. This study aimed to understand the prevalence and clinical features of HBoV in children with ARTI in Shanghai and explore the causative implication of HBoV in ARTI.
METHODS
We retrospectively reviewed the medical records of 349 hospitalized children with ARTI between November 2006 and January 2007. From these children, 351 nasopharyngeal aspirate samples were collected; 325 of the samples were obtained from those with community-acquired ARTI and 26 from those with hospital-acquired ARTI. All samples were routinely screened for seven common respiratory viruses by immunofluorescence and further tested for HBoV by polymerase chain reaction.
RESULTS
HBoV was detected in 16 (4.6%) of the 351 samples, and it was the second most commonly detected virus after respiratory syncytial virus. Three (19%) HBoV-positive samples were dual infection with respiratory syncytial virus or parainfluenza virus type 3. Of the 325 children with community-acquired ARTI, HBoV was identified to be positive in 11 (3.4%), of whom 6 were diagnosed with pneumonia with patchy or interstitial infiltrates in the lung indicated by chest radiography, 3 with bronchitis, and 2 with bronchial asthma exacerbation with attendant lung infection. Out of the 26 children with nosocomial ARTI, 5 (19.2%) had bronchitis which was found to be HBoV positive without co-detection of other viruses. The HBoV-positive children were aged 1.7 months to 43 months and their mean age was 13.7 months. Sixteen (100%) children had cough, 11 (68.8%) had wheezing, and 10 (62.5%) had fever.
CONCLUSIONS
HBoV was circulating in Shanghai during the study period, and which was detected frequently in children with ARTI. HBoV was found to be associated with community-acquired ARTI and may play a pathogenic role in nosocomial ARTI.
背景
人博卡病毒（HBoV）于 2005 年首次报道。现已证实，HBoV 在全世界儿童急性呼吸道感染（ARTI）中普遍存在。本研究旨在了解上海儿童急性呼吸道感染中人博卡病毒的流行情况和临床特征，并探讨 HBoV 在 ARTI 中的致病作用。
方法
我们回顾性分析了 2006 年 11 月至 2007 年 1 月期间 349 例住院 ARTI 患儿的病历。从这些患儿中采集了 351 份鼻咽抽吸物样本；其中 325 份来自社区获得性 ARTI 患儿，26 份来自医院获得性 ARTI 患儿。所有样本均采用免疫荧光法常规筛查七种常见呼吸道病毒，并进一步采用聚合酶链反应检测 HBoV。
结果
在 351 份样本中检测到 16 份（4.6%）HBoV，是继呼吸道合胞病毒之后第二常见的检测病毒。3 份（19%）HBoV 阳性样本与呼吸道合胞病毒或副流感病毒 3 型双重感染。在 325 例社区获得性 ARTI 患儿中，11 例（3.4%）HBoV 阳性，其中 6 例胸部 X 线检查显示肺部斑片状或间质性浸润性肺炎，3 例支气管炎，2 例支气管哮喘加重合并肺部感染。在 26 例医院获得性 ARTI 患儿中，5 例（19.2%）为支气管炎，且 HBoV 阳性，未检测到其他病毒。HBoV 阳性患儿年龄为 1.7 个月至 43 个月，平均年龄为 13.7 个月。16 例（100%）患儿有咳嗽，11 例（68.8%）有喘息，10 例（62.5%）有发热。
结论
在研究期间，上海存在 HBoV 流行，在急性呼吸道感染患儿中经常检测到 HBoV。HBoV 与社区获得性 ARTI 有关，可能在医院获得性 ARTI 中起致病作用。
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