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本文引用的文献

1
Reduction of pain via platelet-rich plasma in split-thickness skin graft donor sites: a series of matched pairs.通过富血小板血浆减轻分层皮片供区疼痛：一系列配对研究。
Diabet Foot Ankle. 2015 Jan 22;6:24972. doi: 10.3402/dfa.v6.24972. eCollection 2015.
2
Platelet and growth factor concentrations in activated platelet-rich plasma: a comparison of seven commercial separation systems.活化富血小板血浆中的血小板和生长因子浓度：七种商业分离系统的比较
J Artif Organs. 2014 Jun;17(2):186-92. doi: 10.1007/s10047-014-0761-5. Epub 2014 Apr 20.
3
Platelet-rich plasma promotes epithelialization and angiogenesis in a splitthickness skin graft donor site.富血小板血浆促进分层皮片供皮区的上皮形成和血管生成。
Med Mol Morphol. 2011 Dec;44(4):233-6. doi: 10.1007/s00795-010-0532-1. Epub 2011 Dec 17.
4
Optimizing platelet-rich plasma gel formation by varying time and gravitational forces during centrifugation.通过在离心过程中改变时间和重力来优化富含血小板血浆凝胶的形成。
J Oral Implantol. 2013 Oct;39(5):525-32. doi: 10.1563/AAID-JOI-D-10-00155. Epub 2011 Apr 11.
5
Effect of topical autologous platelet-rich fibrin versus no intervention on epithelialization of donor sites and meshed split-thickness skin autografts: a randomized clinical trial.局部应用自体富血小板纤维蛋白与不干预对供皮区上皮化及网状自体中厚皮片的影响：一项随机临床试验。
Plast Reconstr Surg. 2008 Nov;122(5):1431-1440. doi: 10.1097/PRS.0b013e318188202c.
6
Proliferation-promoting effect of platelet-rich plasma on human adipose-derived stem cells and human dermal fibroblasts.富含血小板血浆对人脂肪来源干细胞和人皮肤成纤维细胞的增殖促进作用。
Plast Reconstr Surg. 2008 Nov;122(5):1352-1360. doi: 10.1097/PRS.0b013e3181882046.
7
The use of autologous PRP gel as an aid in the management of acute trauma wounds.使用自体富血小板凝胶作为急性创伤伤口管理的辅助手段。
Injury. 2009 Aug;40(8):801-5. doi: 10.1016/j.injury.2008.05.002. Epub 2008 Aug 13.
8
Pain: a review of three commonly used pain rating scales.疼痛：三种常用疼痛评定量表综述
J Clin Nurs. 2005 Aug;14(7):798-804. doi: 10.1111/j.1365-2702.2005.01121.x.
9
Skin grafting.皮肤移植。
Semin Cutan Med Surg. 2003 Dec;22(4):295-305. doi: 10.1016/S1085-5629(03)00079-8.
10
Do autologous growth factors enhance transforaminal lumbar interbody fusion?自体生长因子能否增强经椎间孔腰椎椎间融合术的效果？
Eur Spine J. 2003 Aug;12(4):400-7. doi: 10.1007/s00586-003-0548-5. Epub 2003 May 22.

减轻分层皮片移植供区疼痛；加速愈合并减轻疼痛——富血小板血浆的作用

Reducing split-thickness skin grafting donor site agony; faster healing and decreased pain-role of platelet-rich plasma.

作者信息

Jain Rakesh Kumar, Choudhary Ghisulal M, Gupta Gajendra, Patil Aditya N, Prakash Gautam D, Jain Ayush K

机构信息

Department of Plastic Surgery, SMS Hospital and Medical College, Jaipur, Rajasthan, India.

Department of Pathology, Santokba Durlabji Hospital, Jaipur, Rajasthan, India.

出版信息

Asian J Transfus Sci. 2021 Jul-Dec;15(2):195-198. doi: 10.4103/ajts.AJTS_39_17. Epub 2021 Nov 1.

DOI:10.4103/ajts.AJTS_39_17
PMID:34908754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8628236/
Abstract

INTRODUCTION

The split-thickness skin graft harvested donor site is associated with prolonged healing, discomfort, and pain. Platelet-rich plasma (PRP) contains platelet-derived growth factors and has been widely used in chronic wounds and skin graft donor sites. PRP application is known to accelerate wound epithelialization rates, and also reduce postoperative wound site pain.

MATERIALS AND METHODS

We assessed 20 patients admitted to our hospital service who underwent split-thickness skin grafting (STSGs) with proximal half of the donor site treated with PRP. The dressing was conducted on postoperative day 7, 14, and 21. The donor site healing was assessed with serial photographs and donor site pain measured by numerical rating scale.

RESULTS

Complete healing of wounds (epithelialization) was present in 12 (60%) patients dressed with PRP. Pain on opening dressing was an average of 3.5 in PRP dressed wounds and 6.35 in control wounds. Patients dressed without PRP, none of them had complete epithelialization. All patients had partial healing and were less than the donor site dressed with PRP. Based on these results, skin graft donor site with PRP showed accelerated healing and reduced pain and discomfort compared to control without PRP.

CONCLUSION

PRP is a beneficial adjunct for reducing donor site pain and increased healing of donor site following STSG harvest.

摘要

引言

取皮厚度为中厚皮片的供皮区愈合时间长，伴有不适和疼痛。富血小板血浆（PRP）含有血小板衍生生长因子，已广泛应用于慢性伤口和皮肤移植供皮区。已知应用PRP可加快伤口上皮化速度，并减轻术后伤口部位疼痛。

材料与方法

我们评估了20例在我院接受中厚皮片移植（STSGs）的患者，其供皮区近端一半用PRP治疗。分别在术后第7天、14天和21天进行换药。通过连续拍照评估供皮区愈合情况，并用数字评分量表测量供皮区疼痛程度。

结果

接受PRP换药的12例（60%）患者伤口完全愈合（上皮化）。PRP换药伤口打开敷料时的平均疼痛评分为3.5，对照伤口为6.35。未接受PRP换药的患者均未完全上皮化。所有患者均为部分愈合，且愈合情况不如接受PRP换药的供皮区。基于这些结果，与未使用PRP的对照组相比，使用PRP的皮肤移植供皮区愈合加快，疼痛和不适减轻。

结论

PRP是一种有益的辅助手段，可减轻供皮区疼痛，并促进中厚皮片移植术后供皮区的愈合。