White S I, Friedmann P S, Stratton A
Br J Dermatol. 1986 Oct;115(4):447-52. doi: 10.1111/j.1365-2133.1986.tb06239.x.
We studied 67 patients with multiple contact allergies to determine whether there was an association of this state with any particular HLA antigen. HLA-A, -B and DR antigens were typed by standard serological methods. There was no significant HLA association, although there was an increased frequency of DR4 in those patients who included nickel as one of their sensitivities (64% compared with 33% in controls), and an increase in DR6 in those patients who included sensitivity to a rubber accelerator (45% compared with 16% in controls). However, when the probabilities were corrected for the number of HLA antigens tested and the number of substances in the patch test battery, these associations were no longer statistically significant. We also examined the morphology and numbers of Langerhans cells in epidermal sheets from six subjects with multiple allergies. There were no differences in appearance or numbers of Langerhans cells stained for ATPase, compared with 20 non-allergic controls.
我们研究了67例多种接触性过敏患者，以确定这种状态是否与任何特定的HLA抗原相关。采用标准血清学方法对HLA-A、-B和DR抗原进行分型。虽然对镍过敏的患者中DR4频率增加（64%，而对照组为33%），对橡胶促进剂过敏的患者中DR6增加（45%，而对照组为16%），但未发现显著的HLA相关性。然而，在对所检测的HLA抗原数量和斑贴试验中物质数量进行概率校正后，这些相关性不再具有统计学意义。我们还检查了6例多种过敏受试者表皮片中朗格汉斯细胞的形态和数量。与20例非过敏对照相比，ATP酶染色的朗格汉斯细胞在外观或数量上没有差异。
