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轻度新型冠状病毒2型感染期间的严重高转氨酶血症：一例儿科病例报告及文献综述

Severe hypertransaminasemia during mild SARS-CoV-2 infection: A pediatric case report and literature review.

作者信息

Palpacelli Alessandra, Martelli Gaia, Lattanzi Bianca, Volpini Alessandro, Cazzato Salvatore

机构信息

Pediatric Unit Department of Mother and Child Health Salesi Children's Hospital Ancona Italy.

出版信息

Pediatr Investig. 2021 Oct 5;5(4):310-312. doi: 10.1002/ped4.12300. eCollection 2021 Dec.

DOI:10.1002/ped4.12300
PMID:34909233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8662248/
Abstract

INTRODUCTION

Liver injury during SARS-CoV-2 infection has a multifactorial pathogenesis and it is frequent in pediatric cases.

CASE PRESENTATION

We report a case with severe hypertransaminasemia associated with mild SARS-CoV-2 infection.

CONCLUSION

This highlights the potential need of hepatic function evaluation during acute illness and follow-up even in non-critically ill children with COVID-19.

摘要

引言

新型冠状病毒2（SARS-CoV-2）感染期间的肝损伤具有多因素发病机制，且在儿科病例中很常见。

病例报告

我们报告一例与轻度新型冠状病毒2（SARS-CoV-2）感染相关的严重高转氨酶血症病例。

结论

这凸显了即使在非重症新冠肺炎儿童急性疾病期间及随访过程中进行肝功能评估的潜在必要性。

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本文引用的文献

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The severity and atypical presentations of COVID-19 infection in pediatrics.儿童 COVID-19 感染的严重性和非典型表现。
BMC Pediatr. 2021 Mar 25;21(1):144. doi: 10.1186/s12887-021-02614-2.
2
Transient Severe Liver Injury: A Unique Presentation of COVID-19 Disease in a Pediatric Patient.一过性重度肝损伤：儿童 COVID-19 疾病的独特表现。
Pediatr Infect Dis J. 2021 May 1;40(5):e204-e205. doi: 10.1097/INF.0000000000003104.
3
COVID-19 and Liver Damage: Narrative Review and Proposed Clinical Protocol for Critically ill Pediatric Patients.COVID-19 与肝损伤：危重症儿科患者的叙述性综述及临床方案建议
Clinics (Sao Paulo). 2020 Nov 11;75:e2250. doi: 10.6061/clinics/2020/e2250. eCollection 2020.
4
Fulminant hepatic failure: A rare and devastating manifestation of Coronavirus disease 2019 in an 11-year-old boy.暴发性肝衰竭：一名11岁男孩感染2019冠状病毒病的罕见且严重表现。
Arch Pediatr. 2020 Nov;27(8):502-505. doi: 10.1016/j.arcped.2020.09.009. Epub 2020 Sep 29.
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Abnormal liver enzymes in children and infants with COVID-19: A narrative review of case-series studies.新冠病毒感染儿童和婴儿的肝脏酶异常：病例系列研究的叙述性综述
Pediatr Obes. 2020 Dec;15(12):e12723. doi: 10.1111/ijpo.12723. Epub 2020 Sep 1.
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J Hepatol. 2020 Oct;73(4):807-816. doi: 10.1016/j.jhep.2020.05.002. Epub 2020 May 11.
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J Med Virol. 2020 Oct;92(10):1818-1824. doi: 10.1002/jmv.26036. Epub 2020 Jun 12.
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