Gowthami Buduru, Krishna S V Gopala, Rao D Subba
Faculty of Pharmaceutical Sciences, J.N.T.U.A Ananthapuramu, 515002, Andhra Pradesh, India.
Vagdevi College of Pharmacy and Research Centre, Brahmadevam, Nellore, 524001, Andhra Pradesh, India.
Curr Res Pharmacol Drug Discov. 2021 Jan 30;2:100015. doi: 10.1016/j.crphar.2021.100015. eCollection 2021.
In general, extended release systems have the ability to maintain the drug concentration with in therapeutic range for prolonged period of time, but this may not be the primary requisite for circadian rhythm diseases like asthma, hypertension and rheumatoid arthritis, etc. They require prompt release of drug as per the disease condition, which can be achieved by programmed lag time. Chronotherapeutic drug delivery systems (CDDS) can be achieved by several methods, coating is one amongst them. Though the coating process is complex in terms of methodology, solubility issues and difficulty in achieving the uniform coating, many researchers were successfully employed in development of CDDS. A scientific prospection was made from 2010 to 2020 using PubMed database. Apart from exploration of publication data, we attempt to brief about classification of patents and concordance. The scrutiny also highlights the patents filed on chronotherapeutic systems, focusing particularly on coating technologies. The review is concluded the successful application of coating technology to develop CDDS, as evident from vast number of publications and patents filed.
一般来说，缓释系统有能力在较长时间内将药物浓度维持在治疗范围内，但对于哮喘、高血压和类风湿性关节炎等昼夜节律疾病而言，这可能并非首要要求。这些疾病需要根据病情迅速释放药物，这可通过设定滞后时间来实现。时辰治疗药物递送系统（CDDS）可通过多种方法实现，包衣就是其中之一。尽管包衣过程在方法、溶解性问题以及实现均匀包衣的难度方面较为复杂，但许多研究人员已成功将其用于CDDS的开发。利用PubMed数据库在2010年至2020年期间进行了一次科学展望。除了探索出版数据外，我们还试图简要介绍专利分类和一致性。审查还突出了时辰治疗系统的专利申请，尤其侧重于包衣技术。从大量的出版物和专利申请可以明显看出，综述得出结论认为包衣技术在开发CDDS方面有成功应用。
