Domínguez-Oliva Adriana, Hernández-Ávalos Ismael, Martínez-Burnes Julio, Olmos-Hernández Adriana, Verduzco-Mendoza Antonio, Mota-Rojas Daniel
Master's Program in Agricultural and Livestock Sciences [Maestría en Ciencias Agropecuarias], Xochimilco Campus, Universidad Autónoma Metropolitana (UAM), Mexico City 04960, Mexico.
Clinical Pharmacology and Veterinary Anesthesia, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México (UNAM), Cuautitlán 54714, Mexico.
Animals (Basel). 2023 Mar 31;13(7):1223. doi: 10.3390/ani13071223.
Animal research is considered a key element in advance of biomedical science. Although its use is controversial and raises ethical challenges, the contribution of animal models in medicine is essential for understanding the physiopathology and novel treatment alternatives for several animal and human diseases. Current pandemics' pathology, such as the 2019 Coronavirus disease, has been studied in primate, rodent, and porcine models to recognize infection routes and develop therapeutic protocols. Worldwide issues such as diabetes, obesity, neurological disorders, pain, rehabilitation medicine, and surgical techniques require studying the process in different animal species before testing them on humans. Due to their relevance, this article aims to discuss the importance of animal models in diverse lines of biomedical research by analyzing the contributions of the various species utilized in science over the past five years about key topics concerning human and animal health.
动物研究被认为是生物医学科学发展的关键要素。尽管其应用存在争议并引发了伦理挑战，但动物模型在医学中的贡献对于理解多种动物和人类疾病的病理生理学以及新型治疗方案至关重要。当前的大流行病病理学，如2019冠状病毒病，已在灵长类、啮齿类和猪模型中进行研究，以识别感染途径并制定治疗方案。全球性问题，如糖尿病、肥胖症、神经疾病、疼痛、康复医学和外科技术，在应用于人类测试之前，需要在不同动物物种中研究其过程。鉴于它们的相关性，本文旨在通过分析过去五年科学中使用的各种物种在涉及人类和动物健康的关键主题方面的贡献，来讨论动物模型在生物医学研究不同领域中的重要性。
