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共存肌少症和膝骨关节炎的老年人反复跌倒经历增加:一项横断面研究。

Increased recurrent falls experience in older adults with coexisting of sarcopenia and knee osteoarthritis: a cross-sectional study.

机构信息

Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Department of System Design Engineering, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.

出版信息

BMC Geriatr. 2021 Dec 15;21(1):698. doi: 10.1186/s12877-021-02654-4.


DOI:10.1186/s12877-021-02654-4
PMID:34911490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8672583/
Abstract

BACKGROUND: Sarcopenia and knee osteoarthritis (OA) are two major risk factors for falls in older adults. The coexistence of these two conditions may exacerbate the risk of falls. This cross-sectional study aimed to test the hypothesis that older adults with coexisting sarcopenia and knee OA displayed an increased risk of falls experience. METHODS: Participants recruited from an orthopedic clinic were divided into four groups according to the presence of sarcopenia and radiographic knee OA: isolated sarcopenia, isolated knee OA, sarcopenia + knee OA, and control (i.e., non-sarcopenia with non-OA) groups. We used questionnaires to assess falls experience in the prior 12 months. We performed logistic regression analyses to evaluate the relationship between the four groups and falls experience. RESULTS: Of 291 participants (age: 60-90 years, 78.7% women) included in this study, 25 (8.6%) had sarcopenia + knee OA. Participants with sarcopenia + knee OA had 4.17 times (95% confidence interval: 0.84, 20.6) higher odds of recurrent falls (≥2 falls) than controls after adjustment for age, sex, and body mass index. The increased recurrent falls experience was not clearly confirmed in participants with isolated sarcopenia and isolated knee OA. CONCLUSIONS: People with coexisting of sarcopenia and knee OA displayed increased recurrent falls experience. This study suggests a new concept, "sarcopenic knee OA", as a subgroup associated with higher risk of falls, which should be validated in future large cohort studies. TRIAL REGISTRATION: Not applicable.

摘要

背景:肌少症和膝骨关节炎(OA)是老年人跌倒的两个主要危险因素。这两种情况同时存在可能会增加跌倒的风险。本横断面研究旨在验证以下假设,即同时患有肌少症和膝 OA 的老年人跌倒的风险更高。

方法:从骨科诊所招募的参与者根据是否存在肌少症和放射学膝 OA 分为四组:单纯肌少症组、单纯膝 OA 组、肌少症+膝 OA 组和对照组(即非肌少症且无 OA)。我们使用问卷评估参与者在过去 12 个月中的跌倒经历。我们进行逻辑回归分析来评估四组与跌倒经历之间的关系。

结果:在这项研究中,共纳入了 291 名参与者(年龄 60-90 岁,78.7%为女性),其中 25 名(8.6%)患有肌少症+膝 OA。在调整年龄、性别和体重指数后,肌少症+膝 OA 组的复发性跌倒(≥2 次跌倒)的可能性是对照组的 4.17 倍(95%置信区间:0.84,20.6)。在单纯肌少症和单纯膝 OA 患者中,并未明确证实复发性跌倒经历增加。

结论:同时患有肌少症和膝 OA 的患者复发性跌倒的经历增加。本研究提出了一个新概念,即“肌少症性膝 OA”,作为一个与更高跌倒风险相关的亚组,这需要在未来的大型队列研究中进一步验证。

试验注册:不适用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1458/8672583/034cc0e24fd3/12877_2021_2654_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1458/8672583/b230abc4ce5c/12877_2021_2654_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1458/8672583/034cc0e24fd3/12877_2021_2654_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1458/8672583/b230abc4ce5c/12877_2021_2654_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1458/8672583/034cc0e24fd3/12877_2021_2654_Fig2_HTML.jpg

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[1]
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Medicine (Baltimore). 2025-7-11

[2]
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Musculoskeletal Care. 2025-3

[3]
Association of sarcopenia and its prognostic value in symptomatic knee osteoarthritis among older people in China: the first longitudinal evidence from CHARLS.

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[4]
Prevalence and influencing factors of sarcopenia among patients with knee osteoarthritis: a systematic review and meta-analysis protocol.

BMJ Open. 2024-11-27

[5]
Multi-channel EMG manifestations of upper-extremity muscle coordination imbalance among community-dwelling sarcopenic seniors.

Biomed Eng Online. 2024-11-18

[6]
The effectiveness of vitamin D supplementation in patients with end-stage knee osteoarthritis: Study protocol for a double-blinded, randomized controlled trial.

PLoS One. 2024

[7]
Genetic causality and site-specific relationship between sarcopenia and osteoarthritis: a bidirectional Mendelian randomization study.

Front Genet. 2024-1-8

[8]
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[9]
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[10]
Causal relationship between sarcopenia and osteoarthritis: a bi-directional two-sample mendelian randomized study.

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本文引用的文献

[1]
End-stage knee osteoarthritis with and without sarcopenia and the effect of knee arthroplasty - a prospective cohort study.

BMC Geriatr. 2021-1-4

[2]
Where Two Common Conditions of Aging Meet: Osteoarthritis and Sarcopenia.

Calcif Tissue Int. 2020-9

[3]
Multisite pain and self-reported falls in older people: systematic review and meta-analysis.

Arthritis Res Ther. 2019-2-22

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Falls among older adults with sarcopenia dwelling in nursing home or community: A meta-analysis.

Clin Nutr. 2020-1

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PM R. 2019-3-28

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Interaction between low back pain and knee pain contributes to disability level in individuals with knee osteoarthritis: a cross-sectional study.

Osteoarthritis Cartilage. 2018-7-9

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J Bone Miner Res. 2017-3

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MMWR Morb Mortal Wkly Rep. 2016-9-23

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Osteoporos Int. 2016-8

[10]
Is there an increased risk of falls and fractures in people with early diagnosed hip and knee osteoarthritis? Data from the Osteoarthritis Initiative.

Int J Rheum Dis. 2018-6

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