Department of Physical Therapy, Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of System Design Engineering, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, 223-8522, Japan.
BMC Geriatr. 2021 Dec 15;21(1):698. doi: 10.1186/s12877-021-02654-4.
BACKGROUND: Sarcopenia and knee osteoarthritis (OA) are two major risk factors for falls in older adults. The coexistence of these two conditions may exacerbate the risk of falls. This cross-sectional study aimed to test the hypothesis that older adults with coexisting sarcopenia and knee OA displayed an increased risk of falls experience. METHODS: Participants recruited from an orthopedic clinic were divided into four groups according to the presence of sarcopenia and radiographic knee OA: isolated sarcopenia, isolated knee OA, sarcopenia + knee OA, and control (i.e., non-sarcopenia with non-OA) groups. We used questionnaires to assess falls experience in the prior 12 months. We performed logistic regression analyses to evaluate the relationship between the four groups and falls experience. RESULTS: Of 291 participants (age: 60-90 years, 78.7% women) included in this study, 25 (8.6%) had sarcopenia + knee OA. Participants with sarcopenia + knee OA had 4.17 times (95% confidence interval: 0.84, 20.6) higher odds of recurrent falls (≥2 falls) than controls after adjustment for age, sex, and body mass index. The increased recurrent falls experience was not clearly confirmed in participants with isolated sarcopenia and isolated knee OA. CONCLUSIONS: People with coexisting of sarcopenia and knee OA displayed increased recurrent falls experience. This study suggests a new concept, "sarcopenic knee OA", as a subgroup associated with higher risk of falls, which should be validated in future large cohort studies. TRIAL REGISTRATION: Not applicable.
背景:肌少症和膝骨关节炎(OA)是老年人跌倒的两个主要危险因素。这两种情况同时存在可能会增加跌倒的风险。本横断面研究旨在验证以下假设,即同时患有肌少症和膝 OA 的老年人跌倒的风险更高。
方法:从骨科诊所招募的参与者根据是否存在肌少症和放射学膝 OA 分为四组:单纯肌少症组、单纯膝 OA 组、肌少症+膝 OA 组和对照组(即非肌少症且无 OA)。我们使用问卷评估参与者在过去 12 个月中的跌倒经历。我们进行逻辑回归分析来评估四组与跌倒经历之间的关系。
结果:在这项研究中,共纳入了 291 名参与者(年龄 60-90 岁,78.7%为女性),其中 25 名(8.6%)患有肌少症+膝 OA。在调整年龄、性别和体重指数后,肌少症+膝 OA 组的复发性跌倒(≥2 次跌倒)的可能性是对照组的 4.17 倍(95%置信区间:0.84,20.6)。在单纯肌少症和单纯膝 OA 患者中,并未明确证实复发性跌倒经历增加。
结论:同时患有肌少症和膝 OA 的患者复发性跌倒的经历增加。本研究提出了一个新概念,即“肌少症性膝 OA”,作为一个与更高跌倒风险相关的亚组,这需要在未来的大型队列研究中进一步验证。
试验注册:不适用。
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