Goldstein R A, Mullani N A, Wong W H, Hartz R K, Hicks C H, Fuentes F, Smalling R W, Gould K L
J Nucl Med. 1986 Dec;27(12):1824-9.
Positron imaging provides tomographic images of regional myocardial perfusion but has required an on-site cyclotron. Rubidium-82 (82Rb) is a short-lived (T1/2 = 75 sec) positron emitter available from a generator. In order to determine the feasibility for its use to image acute myocardial infarction, 18 patients with transmural infarctions who had coronary arteriography were given 30-40 mCi of 82Rb intravenously and positron tomographic imaging was carried out within 96 hr after onset of symptoms. Nine simultaneous transaxial slices were obtained for each patient with a positron camera. Images were also reconstructed in a long-axis, short-axis, and three-dimensional display. One study could not be interpreted because of excessive lung activity. Fourteen normals were also studied. The infarct related artery determined by angiography was correctly diagnosed by positron imaging in all 17 patients as were all three prior infarcts by readers blinded to the clinical data. No defects were observed in normals or in noninfarcted myocardial regions. This study indicates that 82Rb should be useful for perfusion imaging in patients with acute myocardial infarction. The short half-life of 82Rb should make it ideal for providing serial assessment of perfusion in patients undergoing thrombolytic therapy.
正电子成像可提供局部心肌灌注的断层图像，但需要现场回旋加速器。铷 - 82（82Rb）是一种可从发生器获得的短寿命（半衰期T1/2 = 75秒）正电子发射体。为了确定其用于急性心肌梗死成像的可行性，对18例接受冠状动脉造影的透壁性梗死患者静脉注射30 - 40毫居里的82Rb，并在症状发作后96小时内进行正电子断层成像。使用正电子相机为每位患者获取9个同时的横轴切片。图像还重建为长轴、短轴和三维显示。由于肺部放射性过高，有一项研究无法解读。还对14名正常人进行了研究。在所有17例患者中，正电子成像正确诊断了血管造影确定的梗死相关动脉，对3例既往梗死灶，阅读者在不知临床资料的情况下也全部正确诊断。在正常人和非梗死心肌区域未观察到缺损。这项研究表明，82Rb应可用于急性心肌梗死患者的灌注成像。82Rb的短半衰期使其成为对接受溶栓治疗患者进行灌注系列评估的理想选择。
