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克罗恩病中的蛋白丢失性肠病：两例罕见病例

Protein-Losing Enteropathy in Crohn's Disease: Two Unusual Cases.

作者信息

Samant Samira, Lyon Danielle R, Asmi Nisar, Jha Pinky

机构信息

Internal Medicine, Medical College of Wisconsin, Wauwatosa, USA.

出版信息

Cureus. 2021 Nov 12;13(11):e19501. doi: 10.7759/cureus.19501. eCollection 2021 Nov.

DOI:10.7759/cureus.19501
PMID:34912640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8666099/
Abstract

Protein-losing enteropathy (PLE) occurs when protein losses throughout the gastrointestinal (GI) tract exceed the liver's ability to produce new protein. This is a rare presentation of Crohn's disease and few reported cases of PLE related to Crohn's exist in the literature. We describe two patients who presented with symptoms of PLE. After extensive diagnostic workup both were diagnosed with Crohn's disease and managed with prednisone.

摘要

当整个胃肠道的蛋白质丢失超过肝脏产生新蛋白质的能力时，就会发生蛋白质丢失性肠病（PLE）。这是克罗恩病的一种罕见表现，文献中报道的与克罗恩病相关的PLE病例很少。我们描述了两名出现PLE症状的患者。经过广泛的诊断检查，两人均被诊断为克罗恩病，并接受泼尼松治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcdf/8666099/5ee32f239f4d/cureus-0013-00000019501-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcdf/8666099/5ec7759353ed/cureus-0013-00000019501-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcdf/8666099/78622d8769ab/cureus-0013-00000019501-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcdf/8666099/57aba0fc745a/cureus-0013-00000019501-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcdf/8666099/dfc95cec9c88/cureus-0013-00000019501-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcdf/8666099/5ee32f239f4d/cureus-0013-00000019501-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcdf/8666099/5ec7759353ed/cureus-0013-00000019501-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcdf/8666099/78622d8769ab/cureus-0013-00000019501-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcdf/8666099/57aba0fc745a/cureus-0013-00000019501-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcdf/8666099/dfc95cec9c88/cureus-0013-00000019501-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dcdf/8666099/5ee32f239f4d/cureus-0013-00000019501-i05.jpg

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本文引用的文献

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Protein-losing enteropathy.蛋白丢失性肠病。
Curr Opin Gastroenterol. 2020 May;36(3):238-244. doi: 10.1097/MOG.0000000000000629.
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Hypoalbuminemia: Pathogenesis and Clinical Significance.低蛋白血症：发病机制与临床意义。
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Protein losing enteropathy: comprehensive review of the mechanistic association with clinical and subclinical disease states.蛋白丢失性肠病：与临床和亚临床疾病状态的机制关联的全面综述
Clin Exp Gastroenterol. 2017 Jul 17;10:147-168. doi: 10.2147/CEG.S136803. eCollection 2017.
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Protein-losing enteropathy in Crohn's disease.克罗恩病中的蛋白丢失性肠病
Acta Gastroenterol Belg. 2006 Oct-Dec;69(4):384-9.