Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, Netherlands.
J Sleep Res. 2022 Dec;31(6):e13532. doi: 10.1111/jsr.13532. Epub 2021 Dec 15.
Hippocampal ripple oscillations have been associated with memory reactivations during wake and sleep. These reactivations should contribute to working memory and memory consolidation respectively. In the past decade studies have moved from being observational to actively disrupting ripple-related activity in closed-loop approaches to enable causal investigations into their function. All together these studies have been able to provide evidence that wake, task-related ripple activity is important for working memory and planning but less important for stabilisation of spatial representations. Rest and sleep-related ripple activity, in contrast, is important for long-term memory performance and thus memory consolidation. In this review, we summarise results from different closed-loop approaches in rodents. Further, we highlight differences in detection and stimulation methods as well as controls and discuss how these differences could influence outcomes.
海马回波震荡与清醒和睡眠期间的记忆再激活有关。这些再激活分别有助于工作记忆和记忆巩固。在过去的十年中，研究从观察性研究转变为采用闭环方法主动干扰与回波相关的活动，以对其功能进行因果研究。所有这些研究都能够提供证据表明，清醒时与任务相关的回波活动对于工作记忆和计划很重要，但对于稳定空间表示则不太重要。相反，休息和睡眠时的回波活动对于长期记忆表现，即记忆巩固很重要。在这篇综述中，我们总结了啮齿动物不同闭环方法的结果。此外，我们强调了检测和刺激方法以及对照的差异，并讨论了这些差异如何影响结果。
