ACS Appl Mater Interfaces. 2021 Dec 29;13(51):60852-60864. doi: 10.1021/acsami.1c16126. Epub 2021 Dec 16.
Cerium oxide nanoparticles (CeONP), having potent antioxidant properties, are highly promising nanomaterials for treatment of diseases in which oxidative stress from excessive reactive oxygen species (ROS) plays a critical role in the pathogenesis and progression. However, most previously reported CeONP formulations were not efficiently cleared from the body, precluding their clinical translation. Herein, we report ultrasmall CeONP that can mitigate activation of macrophages and subsequent acute inflammation. It is found that these CeONP can effectively scavenge reactive species, inhibit macrophage activation, and minimize their recruitment and infiltration to the inflammation site, which lead to alleviation of edema and pain hypersensitivity. Moreover, we demonstrate that CeONP can be effectively excreted from the body within 24 h of systemic administration, minimizing long-term toxicity concerns. Altogether, our findings suggest that CeONP may be explored as both antioxidant and anti-inflammatory agents that can reduce acute inflammation with a better safety profile than existing nanoparticles.
氧化铈纳米颗粒（CeONP）具有强大的抗氧化特性，是极具前景的纳米材料，可用于治疗因活性氧（ROS）过多而导致氧化应激在发病机制和进展中起关键作用的疾病。然而，以前报道的大多数 CeONP 制剂不能有效地从体内清除，从而阻碍了它们的临床转化。在此，我们报告了具有能够减轻巨噬细胞激活及随后的急性炎症的超小 CeONP。研究发现，这些 CeONP 可以有效地清除活性物质、抑制巨噬细胞激活，并减少其向炎症部位的募集和浸润，从而减轻水肿和疼痛过敏。此外，我们还证明，CeONP 在全身给药 24 小时内可有效地从体内排出，最大限度地减少了长期毒性问题。总的来说，我们的研究结果表明，CeONP 可以作为抗氧化剂和抗炎剂来探索，它可以减轻急性炎症，其安全性优于现有的纳米颗粒。
