Second Faculty of Medicine, Charles University Prague, Prague 5, 150 06, Czech Republic.
National Institute of Mental Health, Klecany 250 67, Czech Republlic.
Soc Cogn Affect Neurosci. 2022 Aug 1;17(8):703-711. doi: 10.1093/scan/nsab135.
In 54 participants (41% women) from the Czech arm of the European Longitudinal Study of Pregnancy and Childhood, a national birth cohort with prospectively collected data from their birth until young adulthood, we aimed to study the association between early-life socioeconomic deprivation (ELSD), cognitive ability in adolescence, trait anxiety and resting state functional connectivity of the lateral prefrontal cortex (LPFC) in young adulthood. We found that ELSD was associated with lower cognitive ability in adolescence (at age 13) as well as higher trait anxiety in young adulthood (at age 23/24). Higher cognitive ability in adolescence predicted lower trait anxiety in young adulthood. Resting state functional connectivity between the right LPFC and a cluster of voxels including left precentral gyrus, left postcentral gyrus and superior frontal gyrus mediated the relationship between lower cognitive ability in adolescence and higher trait anxiety in young adulthood. These findings indicate that lower cognitive ability and higher trait anxiety may be both consequences of socioeconomic deprivation in early life. The recruitment of the right LPFC may be the underlying mechanism, through which higher cognitive ability may ameliorate trait anxiety.
在来自捷克的欧洲妊娠和儿童纵向研究（European Longitudinal Study of Pregnancy and Childhood）的 54 名参与者（41%为女性）中，我们旨在研究生命早期社会经济剥夺（ELSD）与青少年认知能力、成年早期特质焦虑和外侧前额叶皮质（LPFC）静息态功能连接之间的关系。该研究是一项全国性出生队列研究，从出生开始收集数据，直到成年早期。我们发现，ELSD 与青少年时期认知能力较低（13 岁时）以及成年早期特质焦虑较高（23/24 岁时）有关。青少年时期较高的认知能力预示着成年早期较低的特质焦虑。青少年时期较低的认知能力和成年早期较高的特质焦虑与右侧 LPFC 与包括左侧中央前回、左侧中央后回和额上回在内的多个体素簇之间的静息态功能连接有关。这些发现表明，较低的认知能力和较高的特质焦虑可能都是生命早期社会经济剥夺的后果。右侧 LPFC 的招募可能是一个潜在的机制，通过这个机制，较高的认知能力可能会减轻特质焦虑。
