儿童慢性肾脏病的心血管疾病危险因素。
Cardiovascular Disease Risk Factors in Chronic Kidney Disease in Children.
机构信息
Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
出版信息
Semin Nephrol. 2021 Sep;41(5):434-438. doi: 10.1016/j.semnephrol.2021.09.005.
Abstract
Over the past 2 decades, cardiovascular (CV) disease has been recognized as one of the most important complications of chronic kidney disease (CKD) and one of the leading causes of death in children with advanced CKD and in young adults who developed CKD during childhood. CV abnormalities develop early and progress during the course of CKD in children. Characterization of the prevalence and evolution of CV disease risk factors in progressive CKD is one of the primary aims of the Chronic Kidney Disease in Children study. In this review, we summarize up-to-date findings from the Chronic Kidney Disease in Children study with a focus on traditional and CKD-related CV risk factors and early subclinical markers of cardiac and vascular structure and function. We also discuss the effect of CV risk factors on progression of CKD.
摘要
在过去的 20 年中，心血管（CV）疾病已被认为是慢性肾脏病（CKD）的最重要并发症之一，也是晚期 CKD 儿童和儿童期发生 CKD 的年轻成人的主要死亡原因之一。CV 异常在儿童 CKD 病程中很早就出现并进展。描述进行性 CKD 中 CV 疾病危险因素的流行和演变是儿童慢性肾脏病研究的主要目标之一。在这篇综述中，我们总结了儿童慢性肾脏病研究的最新发现，重点介绍了传统和 CKD 相关的 CV 危险因素以及心脏和血管结构和功能的早期亚临床标志物。我们还讨论了 CV 危险因素对 CKD 进展的影响。
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