Wu Ti, Zhang Haipeng, Tian Xiaolin, Cao Yang, Wei Dianjun, Wu Xiangkun
Department of Neurology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Department of Clinical Laboratory, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Neuropsychiatr Dis Treat. 2021 Dec 9;17:3589-3595. doi: 10.2147/NDT.S340189. eCollection 2021.
To evaluate the association between neutrophil-to-lymphocyte ratio (NLR) and stroke-associated pneumonia (SAP) in patients with acute ischemic stroke (AIS) without fever and to clarify whether NLR has an advantage over high-sensitivity C-reactive protein (hs-CRP) in predicting SAP.
A total of 434 patients with AIS without fever were assessed in this study. Multivariable analysis was used to evaluate the relationship between NLR and SAP, and the receiver operating characteristic (ROC) curve was used to compare the predictive value of NLR and hs-CRP.
Among the total patients, 18 (4.1%) developed SAP. After adjusting for confounders, NLR (adjusted odds ratio [aOR] = 1.60; 95% confidence interval [CI], 1.30-1.96; < 0.001) remained independently associated with an increased risk of SAP. In addition, the area under the curve (AUC) of NLR (0.862 [0.826-0.893]) was higher than that of hs-CRP (0.738 [0.694-0.779]).
We found that compared with hs-CRP, NLR was significantly associated with the occurrence of SAP in patients with AIS without fever and showed a more effective predictive value for SAP.
评估无发热的急性缺血性卒中（AIS）患者中性粒细胞与淋巴细胞比值（NLR）与卒中相关性肺炎（SAP）之间的关联，并阐明NLR在预测SAP方面是否优于高敏C反应蛋白（hs-CRP）。
本研究共评估了434例无发热的AIS患者。采用多变量分析评估NLR与SAP之间的关系，并使用受试者工作特征（ROC）曲线比较NLR和hs-CRP的预测价值。
在所有患者中，18例（4.1%）发生了SAP。在调整混杂因素后，NLR（调整后的优势比[aOR]=1.60；95%置信区间[CI]，1.30-1.96；P<0.001）仍然与SAP风险增加独立相关。此外，NLR的曲线下面积（AUC）为0.862（0.826-0.893），高于hs-CRP的曲线下面积（0.738[0.694-0.779]）。
我们发现，与hs-CRP相比，NLR与无发热的AIS患者SAP的发生显著相关，并且对SAP显示出更有效的预测价值。
