Qiu Zhuoyin, Guo Tingting, Sheng Xihua, Tang Ying, Du Huaping
Department of Neurology, Suzhou Ninth People's Hospital, Suzhou, People's Republic of China.
Department of Neurology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, People's Republic of China.
Neuropsychiatr Dis Treat. 2022 Oct 14;18:2265-2271. doi: 10.2147/NDT.S384512. eCollection 2022.
This study aims to investigate the prognostic value of the peripheral neutrophil-to-lymphocyte ratio (NLR) in patients with chronic internal carotid artery occlusion (CICAO) complicated by cerebral infarction.
The clinical data of 99 CICAO patients complicated by cerebral infarction were retrospectively analyzed. The modified Rankin Scale (mRS) was used to assess their 3-month prognosis, and a multivariate logistic regression model was established to explore risk factors for poor prognosis.
Multivariate logistic regression analysis demonstrated that NLR (OR=2.114; 95% CI: 1.129-3.959) and baseline National Institute of Health Stroke Scale (NIHSS; OR=1.288, 95% CI: 1.053-1.574) score were risk factors of poor prognosis. The area under the receiver operator characteristic (ROC) curve of NLR in predicting the 3-month outcome after onset was 0.717 (95% CI: 0.606-0.828, <0.000). The optimal cut-off value was 3.22, with a sensitivity of 0.743 and a specificity of 0.791.
NLR is an independent risk factor for the poor prognosis of CICAO patients complicated by cerebral infarction and can serve as an indicator for clinical prognosis.
本研究旨在探讨外周血中性粒细胞与淋巴细胞比值（NLR）在慢性颈内动脉闭塞（CICAO）合并脑梗死患者中的预后价值。
回顾性分析99例CICAO合并脑梗死患者的临床资料。采用改良Rankin量表（mRS）评估其3个月预后，并建立多因素logistic回归模型以探讨预后不良的危险因素。
多因素logistic回归分析显示，NLR（比值比[OR]=2.114；95%置信区间[CI]：1.129-3.959）和基线美国国立卫生研究院卒中量表（NIHSS；OR=1.288，95%CI：1.053-1.574）评分是预后不良的危险因素。NLR预测发病后3个月预后的受试者工作特征（ROC）曲线下面积为0.717（95%CI：0.606-0.828，P<0.000）。最佳截断值为3.22，敏感性为0.743，特异性为0.791。
NLR是CICAO合并脑梗死患者预后不良的独立危险因素，可作为临床预后的指标。
