Fraser J R, Rowley M J, Tait B
University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Rheumatol Int. 1987;7(6):267-9. doi: 10.1007/BF00270527.
Antibody activity against collagen was measured in 53 samples of serum from 48 patients with active signs of epidemic polyarthritis (EPA) following infection with Ross River virus. Activity was higher against denatured collagen than against native collagen, but was within the normal range for each. Determination of HLA phenotypes permitted a search for any relationship between HLA type and differences in collagen antibody levels within the normal range. No relationship was detected with HLA antigens predominating in EPA or with HLA antigens that are associated with high collagen-antibody levels in rheumatoid arthritis (RA), which suggests that the latter associations may represent failure to control collagen antibody levels after the onset of RA. The findings also provide evidence against a role for nonspecific enhancement of humoral immune responses in the pathogenesis of EPA, and constitute a further point of distinction between EPA and RA.
在48例感染罗斯河病毒后出现流行性多关节炎（EPA）活动体征的患者的53份血清样本中，检测了抗胶原蛋白的抗体活性。与天然胶原蛋白相比，抗变性胶原蛋白的活性更高，但两者均在正常范围内。通过测定HLA表型，可探寻HLA类型与正常范围内胶原蛋白抗体水平差异之间的关系。未发现与EPA中占主导地位的HLA抗原或与类风湿性关节炎（RA）中高胶原蛋白抗体水平相关的HLA抗原存在关联，这表明后者的关联可能代表RA发病后未能控制胶原蛋白抗体水平。这些发现也为体液免疫反应的非特异性增强在EPA发病机制中的作用提供了反证，并构成了EPA与RA之间的另一个区别点。
