Ohtake T, Nishikawa J, Machida K, Momose T, Masuo M, Serizawa T, Yoshizumi M, Yamaoki K, Toyama H, Murata H
J Nucl Med. 1987 Jan;28(1):19-24.
Regurgitant fraction (RF) of patients with and without mitral regurgitation (MR) and/or aortic regurgitation (AR) was evaluated by gated cardiac blood-pool scanning using single photon emission computed tomography (SPECT). Using the stroke count image of a short-axis tomogram to separate the right atrium and ventricle, the left ventricular stroke count (LVSC) and right ventricular stroke count (RVSC) were determined. The RF equaled (LVSC - RVSC)/LVSC. Calculated RF in 14 subjects without significant regurgitation by contrast angiography was 5.8 +/- 5.9% (mean +/- s.d.), RF of 17 cases with angiographic regurgitation was 42.5 +/- 16.8% (p less than 0.001). The sensitivity of the radionuclide method compared to angiography was 94% (16/17 cases), and specificity was 100% (14/14 cases). RF of mild Re (1+ or 2+) was 26.0 +/- 8.9% (n = 6) and RF of severe Re (3+ or 4+) was 51.5 +/- 12.7% (n = 11) (p less than 0.001). Correlation between the RF determined with the radionuclide method and with cardiac catheterization was good (y = 5.85 + 0.700 x, r = 0.821, n = 17). We conclude that RF of MR and/or AR can be accurately evaluated by gated cardiac blood-pool scanning using SPECT.
采用单光子发射计算机断层扫描（SPECT）门控心血池显像评估有和无二尖瓣反流（MR）和/或主动脉瓣反流（AR）患者的反流分数（RF）。利用短轴断层图像的每搏计数图像分离右心房和右心室，测定左心室每搏计数（LVSC）和右心室每搏计数（RVSC）。RF等于（LVSC - RVSC）/LVSC。14例经造影检查无明显反流患者计算得出的RF为5.8±5.9%（均值±标准差），17例经造影检查有反流患者的RF为42.5±16.8%（p<0.001）。与造影检查相比，放射性核素法的敏感性为94%（16/17例），特异性为100%（14/14例）。轻度反流（1+或2+）的RF为26.0±8.9%（n = 6），重度反流（3+或4+）的RF为51.5±12.7%（n = 11）（p<0.001）。放射性核素法测定的RF与心导管检查测定的RF之间相关性良好（y = 5.85 + 0.700x，r = 0.821，n = 17）。我们得出结论，使用SPECT门控心血池显像可准确评估MR和/或AR的RF。
