Stadius M L, Williams D L, Harp G, Cerqueira M, Caldwell J H, Stratton J R, Ritchie J L
Am J Cardiol. 1985 Apr 15;55(9):1185-91. doi: 10.1016/0002-9149(85)90660-5.
A new method for measuring left ventricular (LV) volume based on gated single-photon emission computed tomography (SPECT) is described. Preliminary phantom studies showed an excellent correlation between SPECT and observed volumes (r = 0.99, standard error of the estimate [SEE] = 4.9 ml). SPECT was performed 24 hours after biplane contrast LV angiography in 36 patients. Transaxial blood pool tomograms were reconstructed by filtered back projection and reoriented to views orthogonal to the cardiac axes. Volume was calculated from serial short-axis tomograms by determining the base, apex and lateral borders of the LV blood pool, ascertaining the number of pixels in this volume and multiplying by the known volume of a pixel. Gated SPECT volumes were compared with contrast angiographic volumes. At end-systole, r = 0.96 and SEE = 12 ml; at end-diastole, r = 0.81 and SEE = 27 ml. For ejection fraction, r = 0.85 and SEE = 0.06. To test interobserver variation in processing, count data from 5 patients were processed twice (r = 0.98, SEE = 8.3 ml). There is an excellent correlation between SPECT and contrast angiographic volumes at end-systole; at end-diastole the relation is good. SPECT requires no arbitrary background correction, allows systematic isolation of the left ventricle from other overlapping cardiac chambers and requires no geometric assumptions for volume determination. It has promise as a direct method for measuring LV volume in a minimally invasive manner.
描述了一种基于门控单光子发射计算机断层扫描（SPECT）测量左心室（LV）容积的新方法。初步体模研究显示SPECT与观察到的容积之间具有极好的相关性（r = 0.99，估计标准误差[SEE] = 4.9 ml）。对36例患者在双平面对比剂左心室血管造影术后24小时进行SPECT检查。通过滤波反投影重建经轴面血池断层图像，并重新定位到与心脏轴正交的视图。通过确定左心室血池的基部、心尖和外侧边界，计算连续短轴断层图像的容积，确定该容积中的像素数量并乘以已知的像素容积。将门控SPECT容积与对比剂血管造影容积进行比较。在收缩末期，r = 0.96，SEE = 12 ml；在舒张末期，r = 0.81，SEE = 27 ml。对于射血分数，r = 0.85，SEE = 0.06。为测试观察者间在处理过程中的差异，对5例患者的计数数据进行了两次处理（r = 0.98，SEE = 8.3 ml）。在收缩末期，SPECT与对比剂血管造影容积之间具有极好的相关性；在舒张末期，两者关系良好。SPECT不需要任意的背景校正，能够系统地将左心室与其他重叠的心腔隔离开，并且在容积测定时不需要几何假设。它有望成为一种以微创方式测量左心室容积的直接方法。
