Çavdar Safiye, Sürücü Selçuk, Özkan Mazhar, Köse Büşra, Malik Anjum Naeem, Aydoğmuş Evren, Tanış Özgül, Lazoğlu İsmail
Department of Anatomy, Koç University, School of Medicine, Rumelifener Yolu, Istanbul, Turkey.
Department of Anatomy, Koç University, School of Medicine, Rumelifener Yolu, Istanbul, Turkey.
World Neurosurg. 2022 Mar;159:e199-e207. doi: 10.1016/j.wneu.2021.12.029. Epub 2021 Dec 14.
This study aimed to compare the thickness and mechanical properties of the frontal; parietal; temporal; occipital human dura; autogenous grafts (facia lata, temporal fascia, galea aponeurotica); and artificial dura.
Sagittal and transverse dura samples were obtained from standard regions of the cranial dura from 30 autopsies for histologic and mechanical property measurements. Identical measurements were made for the autogenous grafts artificial dura, and the results were statistically analyzed.
The thickness of the temporal (0.35 ± 0.11 mm), parietal (0.44 ± 0.13 mm), frontal (0.38 ± 0.12 mm), and occipital (0.46 ± 0.18 mm) dura showed regional variations. The parietal and occipital dura were significantly thicker than the temporal dura. The occipital dura was considerably thicker than the frontal dura. The frontal and temporal dura of males were significantly thicker than females. The sagittal maximum tensile force measurements were significantly greater than transverse, for the frontal, temporal, and occipital dura. The stiffness measurements in sagittal direction were greater than the measurements in transverse direction for the frontal dura. The mechanical properties and thickness of the autogenous and artificial dura were not similar to the human dura.
The thickness and mechanical properties of the regional cranial dura should be taken into consideration for a better cure and fewer complications. The mechanical properties of sagittal and transverse dura should be kept in mind for the preference of dura material. The present study's data can pave the way to produce artificial regional dura by mimicking the thickness and mechanical properties of the human dura.
本研究旨在比较人类额叶、顶叶、颞叶、枕叶硬脑膜、自体移植物（阔筋膜、颞筋膜、帽状腱膜）和人工硬脑膜的厚度及力学性能。
从30例尸检的颅硬脑膜标准区域获取矢状面和横断面硬脑膜样本，进行组织学和力学性能测量。对自体移植物和人工硬脑膜进行相同测量，并对结果进行统计学分析。
颞叶硬脑膜（0.35±0.11mm）、顶叶硬脑膜（0.44±0.13mm）、额叶硬脑膜（0.38±0.12mm）和枕叶硬脑膜（0.46±0.18mm）的厚度存在区域差异。顶叶和枕叶硬脑膜明显比颞叶硬脑膜厚。枕叶硬脑膜比额叶硬脑膜厚得多。男性的额叶和颞叶硬脑膜明显比女性厚。额叶、颞叶和枕叶硬脑膜的矢状面最大拉伸力测量值明显大于横断面。额叶硬脑膜矢状方向的刚度测量值大于横断面测量值。自体和人工硬脑膜的力学性能和厚度与人类硬脑膜不同。
为了更好地治愈疾病并减少并发症，应考虑区域颅硬脑膜的厚度和力学性能。在选择硬脑膜材料时，应牢记矢状面和横断面硬脑膜的力学性能。本研究的数据可为通过模仿人类硬脑膜的厚度和力学性能来生产人工区域硬脑膜铺平道路。
