Gupta S, Ellis M, Cesario T, Ruhling M, Vayuvegula B
Am J Med. 1987 Jan;82(1):129-31. doi: 10.1016/0002-9343(87)90388-3.
The immunologic status of a patient with disseminated cryptococcosis and no underlying predisposing factor was evaluated. The proportions and numbers of T cells, T cell subsets, B cells and proliferative responses to mitogens and soluble antigens, including cryptococcal antigen, were comparable to those in healthy control subjects; however, the patient had moderately severe hypogammaglobulinemia. The patient continues to do well clinically with intravenous gammaglobulin and antifungal therapy. This study suggests that antibodies might also play a role in the defense against cryptococcal antigen.
对一名患有播散性隐球菌病且无潜在易感因素的患者的免疫状态进行了评估。T细胞、T细胞亚群、B细胞的比例和数量以及对有丝分裂原和可溶性抗原（包括隐球菌抗原）的增殖反应与健康对照受试者相当；然而，该患者患有中度严重的低丙种球蛋白血症。该患者在接受静脉注射丙种球蛋白和抗真菌治疗后临床情况持续良好。这项研究表明，抗体可能也在抵御隐球菌抗原中发挥作用。
