Wright J P, Young G O, Tigler-Wybrandi N
Dig Dis Sci. 1987 Feb;32(2):164-70. doi: 10.1007/BF01297104.
Relapses of Crohn's disease appear to be almost random. If these attacks could be reliably predicted, it might be possible to abort them with early treatment. In order to identify laboratory and clinical parameters that would predict an acute relapse, patients who had been assessed clinically in the three months prior to an attack were studied. Published clinical indices as well as variety of laboratory parameters were measured. The clinical indices and the serum C-reactive protein, orosomucoid, alpha 1-antitrypsin, and iron were increased at the time of the attack as compared to three months earlier, while only the clinical indices, orosomucoid and alpha 1-antitrypsin increased between three months and one month prior to the attack. There was a poor correlation of the parameters to each other. Further prospective studies are needed to determine the specificity of the suggested indices in predicting acute relapses of Crohn's disease.
克罗恩病的复发似乎几乎是随机的。如果能够可靠地预测这些发作，那么或许有可能通过早期治疗来阻止它们。为了确定能够预测急性复发的实验室和临床参数，对在发作前三个月接受过临床评估的患者进行了研究。测量了已发表的临床指标以及各种实验室参数。与三个月前相比，发作时临床指标以及血清C反应蛋白、类黏蛋白、α1抗胰蛋白酶和铁均升高，而在发作前三个月至一个月之间，只有临床指标、类黏蛋白和α1抗胰蛋白酶升高。这些参数之间的相关性较差。需要进一步的前瞻性研究来确定所建议指标在预测克罗恩病急性复发方面的特异性。
