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Macrophage activation, chronic inflammation and gastrointestinal disease.巨噬细胞活化、慢性炎症与胃肠疾病
Gut. 1984 Jul;25(7):760-83. doi: 10.1136/gut.25.7.760.
2
Predictors of acute relapse of Crohn's disease. A laboratory and clinical study.克罗恩病急性复发的预测因素。一项实验室及临床研究。
Dig Dis Sci. 1987 Feb;32(2):164-70. doi: 10.1007/BF01297104.
3
Diminished neutrophil function in Crohn's disease and ulcerative colitis identified by decreased oxidative metabolism and low superoxide dismutase content.通过氧化代谢降低和超氧化物歧化酶含量低确定克罗恩病和溃疡性结肠炎患者中性粒细胞功能减退。
Gut. 1988 Feb;29(2):223-8. doi: 10.1136/gut.29.2.223.

本文引用的文献

1
HLA antigen distribution and HLA haplotype segregation in Crohn's disease.克罗恩病中的HLA抗原分布及HLA单倍型分离
Tissue Antigens. 1980 Jul;16(1):56-61. doi: 10.1111/j.1399-0039.1980.tb00287.x.
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Serum prealbumin: polymorphism in man.
Science. 1965 Aug 27;149(3687):986-7. doi: 10.1126/science.149.3687.986.
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Quantitative studies on the inherited variants of serum alpha-1-antitrypsin.血清α-1-抗胰蛋白酶遗传变异的定量研究。
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Immunochemical quantitation of antigens by single radial immunodiffusion.通过单向辐射免疫扩散法对抗原进行免疫化学定量。
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Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder.与α-1抗胰蛋白酶缺乏症相关的肝硬化：一种先前未被认识的遗传性疾病。
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Alpha-1-antitrypsin, autism, and coeliac disease.
Lancet. 1972 Oct 21;2(7782):883-4. doi: 10.1016/s0140-6736(72)92258-1.
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Data on the genetic linkage relationships between red cell acid phosphatase and alpha1-antitrypsin variants Z, S, I, and F.
Cytogenet Cell Genet. 1976;16(1-5):359-63. doi: 10.1159/000130632.
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Alpha 1 antitrypsin deficiency: a study of the relationship between the Pi system and genetic markers.α1抗胰蛋白酶缺乏症：Pi系统与遗传标记之间关系的研究
Am J Hum Genet. 1975 May;27(3):315-21.
9
Improved estimate of the Gm-Pi linkage.Gm-Pi连锁的改进估计值。
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10
Genetic variation of alpha 1-antitrypsin.α1-抗胰蛋白酶的基因变异
Am J Hum Genet. 1978 Nov;30(6):660-2.

荷兰克罗恩病患者的α1-抗胰蛋白酶水平及表型

alpha 1-Antitrypsin-levels and phenotypes in Crohn's disease in the Netherlands.

作者信息

Klasen E C, Biemond I, Weterman I T

出版信息

Gut. 1980 Oct;21(10):840-2. doi: 10.1136/gut.21.10.840.

DOI:10.1136/gut.21.10.840
PMID:6969207
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1419377/
Abstract

A group of 310 unrelated patients suffering from Crohn's disease has been screened for quantitative and electrophoretic variations of alpha 1-antitrypsin (alpha 1AT). A comparison was made betweeen patients and healthy controls. The distribution of electrophoretic alpha 1AT variants in the patients showed no significant deviation from the controls. The alpha 1AT quantities are significantly higher in the Crohn's disease population than in the controls.

摘要

对一组310名患克罗恩病的非亲属患者进行了α1-抗胰蛋白酶（α1AT）定量和电泳变异筛查。并对患者与健康对照进行了比较。患者中电泳α1AT变异体的分布与对照相比无显著偏差。克罗恩病患者群体中的α1AT量显著高于对照组。