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Integratome analysis of adipose tissues reveals abnormal epigenetic regulation of adipogenesis, inflammation, and insulin signaling in obese individuals with type 2 diabetes.

作者信息

Jin Nana, Lee Heung-Man, Hou Yong, Yu Allen C S, Li Jing-Woei, Kong Alice P S, Lam Candice C H, Wong Simon K H, Ng Enders K W, Ma Ronald C W, Chan Juliana C N, Chan Ting-Fung

机构信息

School of Life Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.

出版信息

Clin Transl Med. 2021 Dec;11(12):e596. doi: 10.1002/ctm2.596.

DOI:10.1002/ctm2.596
PMID:34923751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8684766/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d57/8684766/d733928eefa9/CTM2-11-e596-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d57/8684766/38439d146edf/CTM2-11-e596-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d57/8684766/aaef73783515/CTM2-11-e596-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d57/8684766/d733928eefa9/CTM2-11-e596-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d57/8684766/38439d146edf/CTM2-11-e596-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d57/8684766/aaef73783515/CTM2-11-e596-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d57/8684766/d733928eefa9/CTM2-11-e596-g003.jpg

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本文引用的文献

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Regulatory genomic circuitry of human disease loci by integrative epigenomics.通过整合表观基因组学研究人类疾病相关位点的调控基因组回路。
Nature. 2021 Feb;590(7845):300-307. doi: 10.1038/s41586-020-03145-z. Epub 2021 Feb 3.
2
Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice.Tfe3和Tfeb在转录水平上调节脂肪细胞中过氧化物酶体增殖物激活受体γ2的表达,并介导小鼠脂联素和血糖水平。
Mol Cell Biol. 2017 Jul 14;37(15). doi: 10.1128/MCB.00608-16. Print 2017 Aug 1.
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Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes.
互作组学-转录组分析发现与 2 型糖尿病 GWAS 位点互补的特征。
Sci Rep. 2016 Oct 18;6:35228. doi: 10.1038/srep35228.
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Biology of upper-body and lower-body adipose tissue--link to whole-body phenotypes.上半身和下半身脂肪组织的生物学——与全身表型的联系。
Nat Rev Endocrinol. 2015 Feb;11(2):90-100. doi: 10.1038/nrendo.2014.185. Epub 2014 Nov 4.
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Circadian rhythms and diabetes.昼夜节律与糖尿病
J Diabetes Investig. 2011 Jun 5;2(3):176-7. doi: 10.1111/j.2040-1124.2011.00105.x.
6
Pruning of the adipocyte peroxisome proliferator-activated receptor γ cistrome by hematopoietic master regulator PU.1.造血主调控因子 PU.1 对脂肪细胞过氧化物酶体增殖物激活受体 γ 顺式作用元件的修剪。
Mol Cell Biol. 2013 Aug;33(16):3354-64. doi: 10.1128/MCB.00599-13. Epub 2013 Jun 17.
7
Subcutaneous and visceral adipose tissue gene expression of serum adipokines that predict type 2 diabetes.预测 2 型糖尿病的血清脂肪因子在皮下和内脏脂肪组织中的基因表达。
Obesity (Silver Spring). 2010 May;18(5):884-9. doi: 10.1038/oby.2009.443. Epub 2009 Dec 17.
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Birth Defects Res A Clin Mol Teratol. 2009 Jan;85(1):13-9. doi: 10.1002/bdra.20503.
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