Xu Xiaoxiang, Zheng Jianwei, He Yanze, Lin Kun, Li Shuang, Zhang Ya, Song Peng, Zhou Yuye, Chen Xiong
Department of Otorhinolaryngology-Head and Neck Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
Department of Otorhinolaryngology, Dawu County People's Hospital, Xiaogan, China.
Front Cell Neurosci. 2021 Dec 3;15:791573. doi: 10.3389/fncel.2021.791573. eCollection 2021.
Hearing loss is a common disease due to sensory loss caused by the diseases in the inner ear. The development of delivery systems for inner ear disease therapy is important to achieve high efficiency and reduce side effects. Currently, traditional drug delivery systems exhibit the potential to be used for inner ear disease therapy, but there are still some drawbacks. As nanotechnology is developing these years, one of the solutions is to develop nanoparticle-based delivery systems for inner ear disease therapy. Various nanoparticles, such as soft material and inorganic-based nanoparticles, have been designed, tested, and showed controlled delivery of drugs, improved targeting property to specific cells, and reduced systemic side effects. In this review, we summarized recent progress in nanocarriers for inner ear disease therapy. This review provides useful information on developing promising nanocarriers for the efficient treatment of inner ear diseases and for further clinical applications for inner ear disease therapy.
听力损失是一种常见疾病，由内耳疾病导致的感觉丧失引起。开发用于内耳疾病治疗的给药系统对于实现高效治疗并减少副作用至关重要。目前，传统给药系统显示出用于内耳疾病治疗的潜力，但仍存在一些缺点。随着近年来纳米技术的发展，一种解决方案是开发基于纳米颗粒的内耳疾病治疗给药系统。各种纳米颗粒，如软材料和无机基纳米颗粒，已被设计、测试，并显示出药物的可控递送、对特定细胞靶向性的改善以及全身副作用的减少。在本综述中，我们总结了内耳疾病治疗纳米载体的最新进展。本综述为开发有前景的纳米载体以有效治疗内耳疾病及进一步用于内耳疾病治疗的临床应用提供了有用信息。
