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用于预防和控制新冠疫情的天然产物：可持续生物资源

Natural Products for the Prevention and Control of the COVID-19 Pandemic: Sustainable Bioresources.

作者信息

Singla Rajeev K, He Xuefei, Chopra Hitesh, Tsagkaris Christos, Shen Li, Kamal Mohammad Amjad, Shen Bairong

机构信息

Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, China.

iGlobal Research and Publishing Foundation, New Delhi, India.

出版信息

Front Pharmacol. 2021 Dec 1;12:758159. doi: 10.3389/fphar.2021.758159. eCollection 2021.

DOI:10.3389/fphar.2021.758159
PMID:34925017
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8671886/
Abstract

The world has been unprecedentedly hit by a global pandemic which broke the record of deadly pandemics that faced humanity ever since its existence. Even kids are well-versed in the terminologies and basics of the SARS-CoV-2 virus and COVID-19 now. The vaccination program has been successfully launched in various countries, given that the huge global population of concern is still far behind to be vaccinated. Furthermore, the scarcity of any potential drug against the COVID-19-causing virus forces scientists and clinicians to search for alternative and complementary medicines on a war-footing basis. The present review aims to cover and analyze the etiology and epidemiology of COVID-19, the role of intestinal microbiota and pro-inflammatory markers, and most importantly, the natural products to combat this deadly SARS-CoV-2 virus. A primary literature search was conducted through PubMed and Google Scholar using relevant keywords. Natural products were searched from January 2020 to November 2020. No timeline limit has been imposed on the search for the biological sources of those phytochemicals. Interactive mapping has been done to analyze the multi-modal and multi-target sources. The intestinal microbiota and the pro-inflammatory markers that can serve the prognosis, diagnosis, and treatment of COVID-19 were discussed. The literature search resulted in yielding 70 phytochemicals and ten polyherbal formulations which were scientifically analyzed against the SARS-CoV-2 virus and its targets and found significant. Retrospective analyses led to provide information about 165 biological sources that can also be screened if not done earlier. The interactive analysis mapping of biological sources with phytochemicals and targets as well as that of phytochemical class with phytochemicals and COVID-19 targets yielded insights into the multitarget and multimodal evidence-based complementary medicines.

摘要

一场全球大流行给世界带来了前所未有的冲击，其致死率打破了人类有史以来面临的致命大流行的纪录。如今，就连孩子们都对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）病毒和2019冠状病毒病（COVID-19）的术语和基本知识了如指掌。鉴于全球众多需要关注的人群中仍有很大一部分人远远没有接种疫苗，各国已成功启动了疫苗接种计划。此外，由于缺乏任何针对导致COVID-19的病毒的潜在药物，科学家和临床医生不得不争分夺秒地寻找替代和补充药物。本综述旨在涵盖和分析COVID-19的病因和流行病学、肠道微生物群和促炎标志物的作用，以及最重要的是对抗这种致命的SARS-CoV-2病毒的天然产物。通过PubMed和谷歌学术搜索使用相关关键词进行了一次主要文献检索。天然产物的检索时间为2020年1月至2020年11月。对这些植物化学物质的生物来源检索未设时间限制。已进行交互式绘图以分析多模式和多靶点来源。讨论了可用于COVID-19预后、诊断和治疗的肠道微生物群和促炎标志物。文献检索产生了70种植物化学物质和10种多草药配方，对其针对SARS-CoV-2病毒及其靶点进行了科学分析，发现具有显著效果。回顾性分析提供了有关165种生物来源的信息，如果之前未进行筛查，也可对其进行筛查。生物来源与植物化学物质和靶点的交互式分析绘图，以及植物化学类别与植物化学物质和COVID-19靶点的交互式分析绘图，为多靶点和多模式循证补充药物提供了见解。

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