da Silva Aline Priscilla Gomes
Department of Biosystems and Agricultural Engineering, Michigan State University, East Lansing, MI, USA.
Biocatal Agric Biotechnol. 2021 Oct;37:102179. doi: 10.1016/j.bcab.2021.102179. Epub 2021 Oct 5.
Few licensed drugs and vaccines are available concerning COVID-19, a disease caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2). Furthermore, numerous recent SARS-COV-2 variants of have arisen globally, demonstrating the need to develop broadly protective interventions for different coronavirus strains. Polyphenols are the largest class of natural bioactive compounds, categorized as flavonoids (catechins, quercetin and kaempferol) and non-flavonoids (gallic acid and resveratrol), and these compounds have been described as effective antiviral agents. This is because they can inhibit coronavirus enzymes, blocking replication and infection. The present short manuscript aimed to summarize and report the current evidence from well-known powerful flavonoid (catechin, quercetin, and kaempferol) and non-flavonoid (gallic acid and resveratrol) polyphenols obtained from plant extracts that inhibit coronavirus strains in models or by computer modeling. The knowledge of strategies beyond conventional treatments may be helpful in the development of new coronavirus drugs, treatments/medicines, or formulations.
关于新型冠状病毒肺炎（一种由严重急性呼吸综合征冠状病毒2 ，即SARS-CoV-2引起的疾病），可用的获批药物和疫苗很少。此外，最近全球出现了许多SARS-CoV-2变体，这表明有必要针对不同的冠状病毒毒株开发具有广泛保护作用的干预措施。多酚是最大类别的天然生物活性化合物，分为黄酮类（儿茶素、槲皮素和山奈酚）和非黄酮类（没食子酸和白藜芦醇），这些化合物已被描述为有效的抗病毒剂。这是因为它们可以抑制冠状病毒酶，阻止病毒复制和感染。本简短文稿旨在总结和报告从植物提取物中获得的著名强效黄酮类（儿茶素、槲皮素和山奈酚）和非黄酮类（没食子酸和白藜芦醇）多酚在模型中或通过计算机建模抑制冠状病毒毒株的现有证据。了解常规治疗以外的策略可能有助于开发新型冠状病毒药物、治疗方法/药物或制剂。
