Cassir Nadim, Grandvuillemin Isabelle, Boxberger Manon, Jardot Priscilla, Boubred Farid, La Scola Bernard
Department of Clinical Microbiology, Aix Marseille Université, Institut de Recherche pour le Développement, Assistance Publique des Hôpitaux de Marseille, Microbes, Evolution, Phylogénie et Infection, Marseille, France.
Institut Hospitalo-Universitaire Méditerranée Infection, Marseillle, France.
Front Pediatr. 2021 Dec 2;9:771467. doi: 10.3389/fped.2021.771467. eCollection 2021.
Necrotizing enterocolitis is a life-threatening acquired gastrointestinal disorder among preterm neonates and is associated with a high mortality rate and long-term neurodevelopmental morbidity. No etiologic agent has been definitively established; nonetheless, the most implicated bacteria include members of the genus. We reported here on a case of bacteremia in a preterm neonate with necrotizing enterocolitis, providing more information regarding the potential role of this bacterium in pathogenesis of necrotizing enterocolitis. We emphasized the sporulating form of that confers resistance to disinfectants usually applied for the hospital environmental cleaning. Further works are needed to establish the causal relationship between the occurrence of NEC and the isolation of , with promising perspectives in terms of diagnostic and therapeutic management.
坏死性小肠结肠炎是一种危及生命的获得性胃肠道疾病，在早产儿中较为常见，与高死亡率和长期神经发育疾病相关。目前尚未明确确定其病原体；尽管如此，最常涉及的细菌包括该属的成员。我们在此报告了一例患有坏死性小肠结肠炎的早产儿发生菌血症的病例，提供了关于这种细菌在坏死性小肠结肠炎发病机制中潜在作用的更多信息。我们强调了该菌的芽孢形成形式赋予了对通常用于医院环境清洁的消毒剂的抗性。需要进一步开展工作来确定坏死性小肠结肠炎的发生与该菌的分离之间的因果关系，在诊断和治疗管理方面具有广阔前景。
