Seftel H C, Wyndham C H, dos Santos L A, Pilcher G J, Baker S G
S Afr Med J. 1987 Feb 7;71(3):142-4.
Ischaemic heart disease risk factors, with particular reference to familial hypercholesterolaemia, were studied in 47 male and 6 female Afrikaners, aged 55 years and under, admitted to hospital for coronary bypass surgery. The outstanding feature in this group with severe coronary atherosclerosis demonstrated angiographically was that about half had severe hypercholesterolaemia (greater than or equal to 8.5 mmol/l), and that of the severely hypercholesterolaemic patients about half again had familial hypercholesterolaemia (FH). This yielded an overall prevalence of FH in the 53 cases of 1 in 4 (26.7%) and strongly supports the contention that FH is a major risk factor for severe coronary artery disease in young Afrikaners. The only other risk factor of importance was cigarette smoking, about 80% of the patients being current or ex-smokers.
对47名男性和6名女性阿非利卡人（年龄在55岁及以下）进行了缺血性心脏病风险因素的研究，这些患者因冠状动脉搭桥手术入院。血管造影显示，该组患有严重冠状动脉粥样硬化的突出特点是，约一半患者患有严重高胆固醇血症（大于或等于8.5毫摩尔/升），而在严重高胆固醇血症患者中，约一半又患有家族性高胆固醇血症（FH）。这使得在53例患者中，FH的总体患病率为四分之一（26.7%），有力地支持了FH是年轻阿非利卡人严重冠状动脉疾病主要风险因素的观点。另一个重要的风险因素是吸烟，约80%的患者为当前吸烟者或既往吸烟者。
