Department of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology, Beijing, 100124, P. R. China.
College of Chemistry & Environmental Science, Chemical Biology Key Laboratory of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Hebei University, Baoding, 071002, P. R. China.
Chem Commun (Camb). 2022 Jan 18;58(6):819-822. doi: 10.1039/d1cc06577g.
A simple but efficient fluorogenic probe is reported for accurate imaging of ulcerative colitis hypoxia detection. The hypoxia produced by ulcerative colitis can lead to the upregulation of nitroreductase (NTR). NB-NO2 provides a unique response to NTR, enabling accurate imaging of Dextran sulphate sodium (DSS)-induced ulcerative colitis .
本文报道了一种简单而有效的荧光探针，可用于准确检测溃疡性结肠炎的缺氧情况。溃疡性结肠炎产生的缺氧会导致硝基还原酶（NTR）的上调。NB-NO2 对 NTR 具有独特的响应，能够准确地对葡聚糖硫酸钠（DSS）诱导的溃疡性结肠炎进行成像。
