University of Oxford, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford, OX1 3QX, UK.
University of Oxford, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford, OX1 3QX, UK.
Curr Opin Genet Dev. 2022 Feb;72:110-117. doi: 10.1016/j.gde.2021.11.006. Epub 2021 Dec 17.
The first epithelia to arise in an organism face the challenge of maintaining the integrity of the newly formed tissue, while exhibiting the behavioral flexibility required for morphogenetic processes to occur effectively. Epithelial cells integrate biochemical and biomechanical cues, both intrinsic and extrinsic, in order to bring about the molecular changes which determine their morphology, behavior and fate. In this review we highlight recent advances in our understanding of the various dynamic processes that the emergent epithelial cells undergo during the first seven days of mouse development and speculate what the future holds in understanding the mechanistic bases for these processes through integrative approaches.
在生物体中最先出现的上皮组织面临着维持新形成组织完整性的挑战，同时还需要表现出发生形态发生过程所需的行为灵活性。上皮细胞整合内在和外在的生化和生物力学线索，以带来决定其形态、行为和命运的分子变化。在这篇综述中，我们强调了最近在理解新兴上皮细胞在小鼠发育的头七天中经历的各种动态过程方面的进展，并推测通过综合方法理解这些过程的机制基础的未来前景。
