辛酸和癸酸在癫痫控制中的作用。
Role of octanoic and decanoic acids in the control of seizures.
作者信息
Sills M A, Forsythe W I, Haidukewych D
出版信息
Arch Dis Child. 1986 Dec;61(12):1173-7. doi: 10.1136/adc.61.12.1173.
Abstract
Octanoic and decanoic acid, the major constituents of the Medium Chain Triglyceride (MCT) Emulsion diet, have been detected in appreciable quantities in the peripheral blood of children with intractable seizures treated with the MCT diet. Serum concentrations of these acids as well as beta hydroxybutyrate and acetoacetate rose as the diet was introduced and on full diet showed pronounced diurnal variation and low concentrations in the morning. No correlation between octanoic and decanoic acid concentrations and control of seizures was established, but further studies with octanoic and decanoic acid using animal models are necessary to assess the role of these acids and of control of seizures.
摘要
辛酸和癸酸是中链甘油三酯（MCT）乳剂饮食的主要成分，在用MCT饮食治疗的难治性癫痫患儿的外周血中已检测到相当数量的这些成分。随着饮食的引入，这些酸以及β-羟基丁酸和乙酰乙酸的血清浓度升高，在完全饮食时显示出明显的昼夜变化且早晨浓度较低。辛酸和癸酸浓度与癫痫发作控制之间未建立相关性，但有必要使用动物模型对辛酸和癸酸进行进一步研究，以评估这些酸在癫痫发作控制中的作用。
相似文献
1
Role of octanoic and decanoic acids in the control of seizures.辛酸和癸酸在癫痫控制中的作用。
Arch Dis Child. 1986 Dec;61(12):1173-7. doi: 10.1136/adc.61.12.1173.
2
3
Ketonemia and seizures: metabolic and anticonvulsant effects of two ketogenic diets in childhood epilepsy.酮血症与癫痫发作：两种生酮饮食对儿童癫痫的代谢及抗惊厥作用
Pediatr Res. 1976 May;10(5):536-40. doi: 10.1203/00006450-197605000-00006.
4
HPLC analysis of brain and plasma for octanoic and decanoic acids.采用高效液相色谱法分析大脑和血浆中的辛酸和癸酸。
Clin Chem. 1989 Sep;35(9):1945-8.
5
The medium chain triglyceride diet and intractable epilepsy.中链甘油三酯饮食与难治性癫痫
Arch Dis Child. 1986 Dec;61(12):1168-72. doi: 10.1136/adc.61.12.1168.
6
A randomized trial of classical and medium-chain triglyceride ketogenic diets in the treatment of childhood epilepsy.一项关于经典和中链甘油三酯生酮饮食治疗儿童癫痫的随机试验。
Epilepsia. 2009 May;50(5):1109-17. doi: 10.1111/j.1528-1167.2008.01870.x. Epub 2008 Nov 19.
7
Octanoic acid promotes branched-chain amino acid catabolisms via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats.辛酸通过抑制大鼠肝脏支链α-酮酸脱氢酶激酶来促进支链氨基酸分解代谢。
Metabolism. 2015 Sep;64(9):1157-64. doi: 10.1016/j.metabol.2015.05.014. Epub 2015 Jun 3.
8
Absence of increased blood decanoic acid levels in children with epilepsy treated with classic ketogenic diet.癫痫患儿接受经典生酮饮食治疗后血癸酸水平无升高。
Epileptic Disord. 2019 Aug 1;21(4):366-369. doi: 10.1684/epd.2019.1079.
9
Octanoic acid a major component of widely consumed medium-chain triglyceride ketogenic diet is detrimental to bone.辛酸是广泛食用的中链甘油三酯生酮饮食的主要成分，对骨骼有害。
Sci Rep. 2021 Mar 26;11(1):7003. doi: 10.1038/s41598-021-86468-9.
10
Intestinal absorption of medium chain fatty acids: in vivo studies in pigs devoid of exocrine pancreatic secretion.
Br J Nutr. 1994 Oct;72(4):545-53. doi: 10.1079/bjn19940058.
引用本文的文献
1
Decanoic acid-enriched ketogenic diet in refractory epilepsy.富含癸酸的生酮饮食治疗难治性癫痫
Front Neurol. 2025 Jan 27;16:1524799. doi: 10.3389/fneur.2025.1524799. eCollection 2025.
2
Beta-Hydroxybutyrate (BHB), Glucose, Insulin, Octanoate (C8), and Decanoate (C10) Responses to a Medium-Chain Triglyceride (MCT) Oil with and without Glucose: A Single-Center Study in Healthy Adults.β-羟丁酸（BHB）、葡萄糖、胰岛素、辛酸（C8）和癸酸（C10）对含葡萄糖和不含葡萄糖的中链甘油三酯（MCT）油的反应：一项健康成年人的单中心研究。
Nutrients. 2023 Feb 24;15(5):1148. doi: 10.3390/nu15051148.
3
Metabolic fingerprinting of dogs with idiopathic epilepsy receiving a ketogenic medium-chain triglyceride (MCT) oil.接受生酮中链甘油三酯（MCT）油治疗的特发性癫痫犬的代谢指纹图谱。
Front Vet Sci. 2022 Oct 6;9:935430. doi: 10.3389/fvets.2022.935430. eCollection 2022.
4
K.Vita: a feasibility study of a blend of medium chain triglycerides to manage drug-resistant epilepsy.K.Vita：一种中链甘油三酯混合物用于治疗耐药性癫痫的可行性研究。
Brain Commun. 2021 Jul 23;3(4):fcab160. doi: 10.1093/braincomms/fcab160. eCollection 2021.
5
A ketogenic diet protects DBA/1 and Scn1a mice against seizure-induced respiratory arrest independent of ketosis.生酮饮食可保护DBA/1和Scn1a小鼠免受癫痫诱发的呼吸骤停，且与酮症无关。
Epilepsy Behav. 2021 Sep 29;124:108334. doi: 10.1016/j.yebeh.2021.108334.
6
Using to Advance Our Understanding of the Role of Medium Chain Fatty Acids in Health and Disease.利用[具体内容]增进我们对中链脂肪酸在健康与疾病中作用的理解。 （你提供的原文“Using to Advance...”表述不完整，这里补充了可能缺失的内容进行翻译，你可根据实际情况调整）
Front Cell Dev Biol. 2021 Sep 13;9:722066. doi: 10.3389/fcell.2021.722066. eCollection 2021.
7
Dietary medium chain triglycerides for management of epilepsy: New data from human, dog, and rodent studies.饮食中链甘油三酯治疗癫痫：来自人体、犬和啮齿动物研究的新数据。
Epilepsia. 2021 Aug;62(8):1790-1806. doi: 10.1111/epi.16972. Epub 2021 Jun 25.
8
Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling.癸酸通过不依赖葡萄糖和胰岛素信号抑制 mTORC1 活性。
Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23617-23625. doi: 10.1073/pnas.2008980117. Epub 2020 Sep 2.
9
Abolishing spontaneous epileptiform activity in human brain tissue through AMPA receptor inhibition.通过 AMPA 受体抑制消除人脑组织中的自发性癫痫样活动。
Ann Clin Transl Neurol. 2020 Jun;7(6):883-890. doi: 10.1002/acn3.51030. Epub 2020 May 19.
10
A double-blinded randomised dietary supplement crossover trial design to investigate the short-term influence of medium chain fatty acid (MCT) supplement on canine idiopathic epilepsy: study protocol.一项双盲随机膳食补充剂交叉试验设计，以研究中链脂肪酸（MCT）补充剂对犬特发性癫痫的短期影响：研究方案。
BMC Vet Res. 2019 May 30;15(1):181. doi: 10.1186/s12917-019-1915-8.
本文引用的文献
1
2
Medium and long chain fat absorption in patients with cirrhosis.肝硬化患者中、长链脂肪的吸收
J Clin Invest. 1966 Aug;45(8):1317-25. doi: 10.1172/JCI105438.
3
The medium chain triglyceride diet and intractable epilepsy.中链甘油三酯饮食与难治性癫痫
Arch Dis Child. 1986 Dec;61(12):1168-72. doi: 10.1136/adc.61.12.1168.
Zotero 插件