Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Department of Clinical Genetics, Shengjing Hospital of China Medical University, Shenyang, 110004, China.
Mol Med. 2021 Dec 20;27(1):159. doi: 10.1186/s10020-021-00421-0.
Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions as an oncogene. XIST is involved in multiple aspects of carcinogenesis, including tumor onset, progression, and prognosis. In our review, we collected and analyzed the recent studies on the impact of XIST in human tumor development. The multilevel molecular functions of XIST in human tumors are comprehensively reviewed to clarify the pathologic mechanisms and to offer a novel direction for further study.
长链非编码 RNA（lncRNA）X 失活特异性转录物（XIST）是哺乳动物中从 XIST 基因衍生而来的重要 lncRNA。XIST 在许多肿瘤中异常表达，在大多数肿瘤中，XIST 作为癌基因发挥作用。XIST 参与了肿瘤发生、发展和预后的多个方面。在我们的综述中，我们收集和分析了最近关于 XIST 在人类肿瘤发展中的影响的研究。全面综述了 XIST 在人类肿瘤中的多层次分子功能，以阐明病理机制，并为进一步研究提供新的方向。
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