Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Infectious Ophthalmologic Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Clin Transl Oncol. 2023 Jul;25(7):2015-2042. doi: 10.1007/s12094-023-03110-y. Epub 2023 Feb 28.
Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties. X inactive-specific transcript (XIST) is a known lncRNA that has been implicated in X chromosome silencing in female cells. Dysregulation of XIST is associated with an increased risk of various cancers. Therefore, XIST can be a beneficial prognostic biomarker for human malignancies. In this review, we attempt to summarize the emerging roles of XIST in human cancers.
长非编码 RNA（lncRNA）是一类含有 200 个核苷酸以上但不编码蛋白质的非编码 RNA。在肿瘤发生过程中，lncRNA 可以具有致癌和抑癌双重特性。X 失活特异性转录本（XIST）是一种已知的 lncRNA，它参与了女性细胞中 X 染色体的沉默。XIST 的失调与多种癌症的风险增加有关。因此，XIST 可以作为人类恶性肿瘤有预后价值的生物标志物。在这篇综述中，我们试图总结 XIST 在人类癌症中的作用。
