Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
BMC Gastroenterol. 2021 Dec 20;21(1):483. doi: 10.1186/s12876-021-02071-2.
The relationship between fibrosis-4 (FIB-4) index and clinical outcomes in patients with acute kidney injury (AKI) is unclear. We aimed to investigate the association between FIB-4 index and all-cause mortality in critically ill patients with AKI.
We used data from the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III) database (v1.4). The FIB-4 score was calculated using the existing formulas. logistic regression model, and Cox proportional hazards model were used to assessed the relationship between the FIB-4 index and in-hospital,28-day and 90-day mortality, respectively.
A total of 3592 patients with AKI included in the data analysis. 395 (10.99%) patients died during hospitalization and 458 (12.74%) patients died in 28-day. During the 90-day follow-up, 893 (22.54%) patients were dead. An elevated FIB-4 value was significantly associated with increased in-hospital mortality when used as a continuous variable (odds ratio [OR] 1.183, 95% confidence interval [CI] 1.072-1.305, P = 0.002) and as a quartile variable (OR of Q2 to Q4 1.216-1.744, with Q1 as reference). FIB-4 was positively associated with 28-day mortality of AKI patients with hazard ratio (HR) of 1.097 (95% CI 1.008, 1.194) and 1.098 (95% 1.032, 1.167) for 90-day mortality, respectively.
This study demonstrated the FIB-4 index is associated with clinical outcomes in critically ill patients with acute kidney injury.
纤维化 4 指数（FIB-4）与急性肾损伤（AKI）患者的临床结局之间的关系尚不清楚。我们旨在研究 FIB-4 指数与 AKI 重症患者全因死亡率之间的关系。
我们使用 Multiparameter Intelligent Monitoring in Intensive Care III（MIMIC-III）数据库（v1.4）中的数据。使用现有的公式计算 FIB-4 评分。使用逻辑回归模型和 Cox 比例风险模型分别评估 FIB-4 指数与住院期间、28 天和 90 天死亡率之间的关系。
共有 3592 例 AKI 患者纳入数据分析。395 例（10.99%）患者住院期间死亡，458 例（12.74%）患者在 28 天内死亡。在 90 天随访期间，有 893 例（22.54%）患者死亡。当 FIB-4 值作为连续变量（优势比[OR]1.183，95%置信区间[CI]1.072-1.305，P=0.002）和四分位数变量（Q2 至 Q4 的 OR 为 1.216-1.744，以 Q1 为参考）使用时，升高的 FIB-4 值与住院期间死亡率显著相关。FIB-4 与 AKI 患者 28 天死亡率呈正相关，风险比（HR）为 1.097（95%CI1.008，1.194）和 90 天死亡率的 1.098（95%CI1.032，1.167）。
本研究表明，FIB-4 指数与 AKI 重症患者的临床结局相关。
