Department of Radiology, The affiliated hospital of Shaanxi university of Chinese medicine, Xian Yang, China.
Department of Radiology, The affiliated hospital of Shaanxi university of Chinese medicine, -2# Weiyang Western Road, 712000, Xian Yang, China.
Cancer Imaging. 2021 Dec 20;21(1):68. doi: 10.1186/s40644-021-00441-3.
To determine whether the pulmonary MR imaging with free-breathing radial 3D fat-suppressed T1-weighted gradient echo (r-VIBE) sequence can detect lung lesions and display lesion profiles with an accuracy comparable to that of computed tomography (CT), which is the reference standard in this study.
Sixty-three consecutive patients were prospectively enrolled between October, 2016 and March, 2017. All the patients received both 3T MRI scanning with a free-breathing r-VIBE sequence and chest standard CT. Morphologic features of lesions were evaluated by two radiologists with a 5-point system. Chest standard CT were used as reference standard. Weighted kappa analysis and chi-squared test were used to determine both inter-observer agreement and inter-method agreement.
A total of 210 solid pulmonary nodules or masses and 1 ground-glass nodule were detected by CT. Compared to CT, r-VIBE correctly detected 95.7% of pulmonary nodules, including 100% of detection rate with diameter greater than 6 mm, 92.3% of pulmonary nodules with diameter between 4 and 6 mm, and 83.3% of pulmonary nodules with diameter less than 4 mm The inter-method agreements between r-VIBE and standard-dose CT were either "substantial" or "excellent" in the evaluation of following features of pulmonary nodules with diameter more than 10mm: including lobulation, spiculation, convergence of vessels, bubble-like attenuation, cavitation and mediastinal lymph node enlargement (0.605≤K≤1.000; P<0.0001). However, K values for inter-method agreements were significant but "moderate" or "poor" for evaluating pleural tag, halo, and calcification (0.355≤ K≤0.451; P<0.0001).
The use of pulmonary MR imaging with r-VIBE showed high detection rate of pulmonary nodules and inter-method agreement with CT. It is also useful for nodule morphologic assessment.
确定 3T 磁共振成像（MRI）自由呼吸径向 3D 脂肪抑制 T1 加权梯度回波（r-VIBE）序列能否检测到肺部病变并显示病变特征，其诊断准确性与 CT 相当，后者为本研究的参考标准。
2016 年 10 月至 2017 年 3 月，连续前瞻性纳入 63 例患者。所有患者均接受了 3T MRI 扫描（自由呼吸 r-VIBE 序列）和胸部标准 CT 检查。两位放射科医生采用 5 分制评估病变的形态学特征。以胸部标准 CT 为参考标准。采用加权 Kappa 分析和卡方检验评估观察者间和方法间的一致性。
CT 共发现 210 个实性肺结节或肿块和 1 个磨玻璃结节。与 CT 相比，r-VIBE 正确检测到 95.7%的肺结节，其中直径大于 6mm 的肺结节检测率为 100%，直径为 4~6mm 的肺结节检测率为 92.3%，直径小于 4mm 的肺结节检测率为 83.3%。对于直径大于 10mm 的肺结节，r-VIBE 与标准剂量 CT 之间的方法间一致性在评估以下特征时为“高度一致”或“极好”：分叶征、毛刺征、血管集束征、空泡征、空洞征和纵隔淋巴结肿大（0.605≤K≤1.000；P<0.0001）。然而，对于胸膜尾征、晕征和钙化的评估，方法间 K 值虽然显著，但为“中度一致”或“较差”（0.355≤K≤0.451；P<0.0001）。
r-VIBE 自由呼吸肺部 MRI 成像具有较高的肺结节检测率，与 CT 之间具有高度的方法间一致性，还可用于评估结节形态。
