Varey A M, Dean B M, Walker R, Bone A J, Baird J D, Cooke A
Immunology. 1987 Jan;60(1):131-4.
Several immunological responses of the spontaneously diabetic BB rat colony in Edinburgh designated (BB/E) have been studied. The proliferative responses to Con A and LPS, ability to make IL-2 and to show NK activity have been studied using diabetic and non-diabetic BB/E rats and normal Wistar rats. Our data suggest that the diabetic animals in the BB/E colony do not have marked deficiencies in any of these parameters. Lymphopenia and depressed T-cell responses do not appear to be a prerequisite for the development of diabetes in the BB/E colony.
对爱丁堡自发糖尿病BB大鼠群体(命名为BB/E)的几种免疫反应进行了研究。使用糖尿病和非糖尿病的BB/E大鼠以及正常的Wistar大鼠,研究了它们对刀豆蛋白A(Con A)和脂多糖(LPS)的增殖反应、产生白细胞介素-2(IL-2)的能力以及自然杀伤(NK)活性。我们的数据表明,BB/E群体中的糖尿病动物在这些参数中均无明显缺陷。淋巴细胞减少和T细胞反应降低似乎不是BB/E群体中糖尿病发生的先决条件。