Ozawa S, Ueda M, Ando N, Abe O, Shimizu N
Int J Cancer. 1987 Mar 15;39(3):333-7. doi: 10.1002/ijc.2910390311.
EGF receptor levels were investigated in esophageal squamous-cell carcinoma tissues from 31 patients. Twenty-two (71%) of these cancer tissues exhibited significantly higher 125I-EGF binding activity than normal mucosa in the adjacent non-cancerous tissues. These EGF receptor levels were then compared on the basis of pathological findings including lymph-node metastasis, depth of invasion, differentiation type, vascular invasion, infiltration and location of the lesion. Unlike previous reports on breast and bladder cancers, our study showed no obvious correlation between these pathological characteristics and the EGF receptor levels in esophageal carcinomas. Immunohistochemical staining with the anti-EGF receptor monoclonal antibody detected EGF receptors in squamous cells of the cancer tissues as well as in the basal cells of nearby normal epithelium. Since the basal cells have proliferative potential in the esophagus, the increase in EGF receptor levels in these cells may possibly be associated with the development of human esophageal squamous-cell cancer.
对31例患者的食管鳞状细胞癌组织中的表皮生长因子（EGF）受体水平进行了研究。其中22例（71%）癌组织的¹²⁵I-EGF结合活性显著高于相邻非癌组织中的正常黏膜。然后根据包括淋巴结转移、浸润深度、分化类型、血管浸润、病变浸润和位置等病理结果对这些EGF受体水平进行了比较。与先前关于乳腺癌和膀胱癌的报道不同，我们的研究表明这些病理特征与食管癌中的EGF受体水平之间没有明显相关性。用抗EGF受体单克隆抗体进行免疫组织化学染色，在癌组织的鳞状细胞以及附近正常上皮的基底细胞中检测到了EGF受体。由于食管中的基底细胞具有增殖潜能，这些细胞中EGF受体水平的升高可能与人类食管鳞状细胞癌的发生有关。
