Bergfeldt L, Möller E
J Rheumatol. 1986 Oct;13(5):941-3.
HLA-B27 associated rheumatic syndromes have been found in 13% of more than 200 pacemaker treated Caucasian men. Furthermore, a significantly increased frequency of HLA-B27 was found in pacemaker treated men without HLA-B27 associated rheumatic disorders. Consequently, an HLA-B27 associated disease process seems to be the cause of heart block development in 15 to 20% of Caucasian pacemaker treated men. The purpose of our study was to find out if the HLA-B27 associated disease process was equally common in pacemaker treated women. Eighty-five pacemaker treated women with second and third degree heart block were HLA typed for B27, and HLA-B27 positive individuals were further examined for the presence of associated rheumatic disorders. HLA-B27 was present in 7 women, 8.2%, similar to the frequency in the general population, and none of them had an associated rheumatic disease. Thus, there is a significant sex linked difference in the susceptibility to HLA-B27 associated heart block.
在接受起搏器治疗的200多名白种男性中，13%被发现患有HLA - B27相关的风湿综合征。此外，在未患HLA - B27相关风湿性疾病的接受起搏器治疗的男性中，HLA - B27的频率显著增加。因此，在15%至20%接受起搏器治疗的白种男性中，HLA - B27相关的疾病过程似乎是心脏传导阻滞发生的原因。我们研究的目的是查明在接受起搏器治疗的女性中，HLA - B27相关的疾病过程是否同样常见。对85名患有二度和三度心脏传导阻滞且接受起搏器治疗的女性进行了HLA - B27分型，对HLA - B27阳性个体进一步检查是否存在相关的风湿性疾病。7名女性（8.2%）存在HLA - B27，这与一般人群中的频率相似，且她们中没有人患有相关的风湿性疾病。因此，在对HLA - B27相关心脏传导阻滞的易感性方面存在显著的性别关联差异。
